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Measurements of β-arrestin-2 recruitment by the PathHunter enzyme complementation assay in CHO cells that overexpressed human µ-opioid receptors. β-arrestin-2 recruitment was measured in terms of an increase in luminescence after the administration of morphine, methadone, and fentanyl (A). Δ% internalization of µ-opioid receptor after the administration of morphine, methadone, and fentanyl (B). Each column represents the mean with SEM of three independent experiments.
