Figure 2.

Comparisons of pain hypersensitivity following the variants of SNI and SNT. Temporal changes of pain hypersensitivity were showed in (a) thermal hyperalgesia, noxious radiant heat stimulus-evoked thermal threshold was defined as the withdrawal latency (s); (b) mechanical hyperalgesia, safety pin-evoked withdrawal response period was measured as the pin-prick duration (s); and (c) mechanical allodynia, the degree of von Frey monofilament-evoked withdrawal response was expressed as the mechanical threshold (g). Behavioral assessments were represented as mean ± SD (n = 5 at each POW in each group). Student’s t test was applied to examine the differences against Sham at each time point. * p < 0.05 indicated a significant difference versus Sham (hypersensitivity) and # p < 0.05 indicated a significant difference versus Sham (hyposensitivity). Two-way repeated measures ANOVA was also performed following the Bonferroni’s post hoc test.