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. 2016 May 13;12:1744806916647373. doi: 10.1177/1744806916647373

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — MAP kinase activity is not required for the maintenance of pre-LTP. (a) Bath application of PD98059 (100 µM) did not affect the maintenance of pre-LTP. Top: sample traces of eEPSCs with paired-pulse stimulation at 50 ms interstimulus interval during baseline (1) and 60 min after the pre-LTP (2) at a holding membrane potential of −60 mV. Middle: a time course plot of a representative single example. Bottom: time course plot of PPR for this neuron. The arrow donates the time of pre-LTP induction. (b) Pooled data to illustrate the time course of pre-LTP and changes in PPR with application of PD98059 after pre-LTP induction stimulation. Top: pre-LTP of PD98059 (n = 8/4) after the stimulation. Bottom: PPR for these neurons. (c) Summary of the effects of pre-LTP and PD98059 after pre-LTP induction stimulation. The amplitudes of eEPSCs were not significantly different between pre-LTP and PD98059 after pre-LTP (one-way ANOVA, F_1,28 = 0.238, p > 0.05, NS). The mean amplitudes of eEPSCs were determined at 50–60 min after the pre-LTP induction stimulation. Error bars represent SEM.