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. 2016 May 4;12:1744806916646381. doi: 10.1177/1744806916646381

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Reversal of hyperexcitability of DRG neurons in CCI rats by GRK6 overexpression. (A) Bright-field (a), GRK6 LV-GFP (b), DiI fluorescence (c), and merge of GFP and Dil fluorescence (d) images of acutely dissociated DRG neurons. A hind paw innervating DRG neuron infected by GRK-LV is indicated by arrow. Bar = 50 µm. (B) GRK6 overexpression significantly hyperpolarized the RP of hind paw innervating DRG neurons. *p < .05 vs. NC-LV. (C) GRK6 overexpression notably depolarized the AP threshold (*p < .05 vs. NC-LV). (D) GRK6 overexpression also markedly increased rheobase. *p < .05 vs. NC-LV. (E, G) Examples of APs by 100 and 300 pA ramp current injection from NC-LV and GRK6-LV-infected DRG neurons. (F, H) Bar graph showed a significant decrease in numbers of APs evoked by 100 and 300 pA ramp current stimulation by GRK6 overexpression. *p < .05 vs. NC-LV. RP: resting membrane potential; AP: action potential; NC-LV: negative control lentivirus.