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. 2016 Jul 20;2(7):e1600692. doi: 10.1126/sciadv.1600692

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Copyright © 2016, The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — (A) Dose-response curve of USP21 activity inhibition by wild-type ubiquitin and the Ubv10 ubiquitin design. IC₅₀ concentrations were evaluated as the ubiquitin concentration inhibiting USP21 activity by 50%. The Ubv10 dose-response curve has an IC₅₀ value of 4.2 nM. (B) A strong correlation exists between the IC₅₀ concentrations and the log-transformed deep sequencing counts.