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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Nat Chem Biol. 2015 Dec;11(12):909–916. doi: 10.1038/nchembio.1964

Figure 3. A bacterial smORFs with metabolic function.

Figure 3

In bacteria, the cellular response to glucotoxicity includes a unique RNA that includes a smORF57. SgrS is an RNA that inhibits the translation of the glucose transporter ptsG mRNA through an antisense interaction. Also, a smORF present on the SgrS RNA produces an SEP called SgrT that inhibits glucose transport activity of the PtsG protein thereby inhibiting glucose uptake via two distinct mechanisms.