Table 2.

Genetic Studies of Lp(a) as a Risk Factor for Aortic Valve Disease

Author	Year	Study Design	Size	Key Findings
Thanassoulis [17]	2013	GWAS, cohort	6,942 (AVC analysis), 28,193 (MDCS analysis of AS), 10,400 (CCHS analysis of AS)	SNP rs10455872 in LPA is associated with AVC (OR per G allele 2.05 (CI 1.63–2.57, p = 9.0×10−10)) and with incident AS: HR 1.68 per risk allele (CI 1.32–2.15; p = 3×10−5) in MDCS, HR 1.6 for presence of at least one risk allele (CI 1.12–2.28, p = 0.01) in CCHS.
Kamstrup [12]	2014	Cohort	77,680	Relative risk of AV stenosis of 1.6 (95% CI 1.2–2.1) for a 10-fold increase in genetically determined Lp(a) values (includes rs10455872, rs3798220, and KIV-2 repeats).
Arsenault [14]	2014	Cohort, with case-control replication	17,553	Risk of AV stenosis increases with number of rs10455872 G alleles: 1 allele, unadjusted HR 1.78 (CI 1.11–2.87); 2 alleles, unadjusted HR 4.83 (CI 1.77–13.20). Case-control: rs10455872 associated with AV stenosis, OR 1.57 (95% CI 1.10–2.26).
Langsted [13]	2015	Cohort	100,578	Causal risk ratio (CRR) for AS associated with LPA SNPs (rs10455872 and rs3798220) for 1 SD increase in Lp(a): 1.38 (CI 1.23–1.55). For LPA KIV-2, CRR for AS for 1 SD increase in Lp(a): 1.21 (CI 1.06–1.40).