Table 4.

Cytotoxicity and NF-κB and K-Ras inhibition of compounds isolated from M. caeruleaa.

Compound	Cytotoxicityb	NF-κB p65 inhibitionc	K-Ras inhibitiond
1	>10	>10	9.4
6	0.1	5.3	3.1
7	0.3	>10	>10
8	>10	>10	3.7
Paclitaxele	0.0008
Rocaglamidee		0.075
Methyl			0.028
Rocaglatee

^aIC₅₀ values are the concentration required for 50% inhibition of cell viability after 72 h of incubation with a given test compound and were calculated using nonlinear regression analysis with measurements performed in triplicate and representative of three independent experiments in which the values generally agreed within 10%

^bRepresented as IC₅₀ values (µM) toward the HT-29 human colon cancer cell line

^cRepresented as IC₅₀ values (µM) for NF-κB inhibition in HeLa cells

^dRepresented as IC₅₀ values (µM) for K-Ras inhibition in HT-29 cells

^ePositive control