Study 5, the effects of injection of saline or 8-OH-DPAT (100 ug/kg, sc; a 5-HT1A receptor agonist) on emesis and esophageal contractions 30 min after injection (Drug) and after gastric distension (Drug + distension; 10 min of 4 ml of balloon inflation; n = 7/group)(A) Number of emetic episodes. (B) Cumulative proportion of animals showing the latency to the first emetic episode. (C) Number of esophageal contractions. Red dots = scatter plot of raw data; bars = mean ± SEM. * p < 0.05, LSD-test, Fig. 6A and 6C, and Log-rank test, Fig. 6B.