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. Author manuscript; available in PMC: 2016 Nov 12.
Published in final edited form as: Genes Immun. 2016 May 12;17(5):283–297. doi: 10.1038/gene.2016.19

Figure 8. Model for the role of H3K4 methylation during CD4 T cell activation.

Figure 8

A) In naïve cells, H3K4me2 dominance results in upregulation of expression. Low expression genes increase in H3K4me2, allowing H3K4me3 marks to be deposited in order to sustain increased expression. Genes whose H3K4me3 enrichment is not increased return to baseline expression. Memory cells generally bypass these mechanisms, starting with significantly higher promoter H3K4me3 at baseline. Time points at which these changes were recorded are documented.