Table 1.
Top pathways obtained via Signaling Pathway Impact Analysis (SPIA) for genes changing in promoter H3K4me3 in naïve CD4 T cells 1 day after activation.
| Database | Pathway | # of genes in pathway | # of genes differentially enriched at 24 h | % of pathway | p-value |
|---|---|---|---|---|---|
| Reactome | Signaling by GPCR | 1002 | 227 | 23% | 3.08E-41 |
| KEGG | Olfactory transduction | 397 | 156 | 39% | 3.06E-65 |
| Reactome | Immune System | 1075 | 129 | 12% | 0.0000135 |
| KEGG | PI3K-AKT signaling pathway | 334 | 52 | 16% | 0.000366 |
| Reactome | Cytokine Signaling in Immune system | 303 | 45 | 15% | 0.000193 |
| PANTHER | WNT signaling pathway | 215 | 35 | 16% | 0.00138 |
| Reactome | Interferon Signaling | 189 | 32 | 17% | 0.000151 |
| Reactome | Ion channel transport | 169 | 30 | 18% | 0.00154 |
| KEGG | JAK-STAT signaling pathway | 156 | 29 | 19% | 0.00072 |
| PANTHER | Integrin signalling pathway | 109 | 22 | 20% | 0.00111 |
| Reactome | Cell-Cell communication | 106 | 21 | 20% | 0.00125 |
| Reactome | Stimuli-sensing channels | 94 | 20 | 21% | 0.001247 |
| Reactome | Meiotic recombination | 75 | 18 | 24% | 0.000176 |
| Reactome | PKMTs methylate histone lysines | 59 | 17 | 29% | 0.000009713 |
| Reactome | HDMs demethylate histones | 43 | 13 | 30% | 0.000115 |
| Reactome | RNA Polymerase I Promoter Opening | 52 | 12 | 23% | 1.52E-07 |
| NCI | Internalization of ErbB1 | 32 | 11 | 34% | 0.000316 |
| KEGG | Taste transduction | 44 | 10 | 23% | 0.00125 |
| Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 31 | 10 | 32% | 0.00134 |
| BioCarta | 41bb-dependent immune response | 6 | 2 | 33% | 7.12E-06 |