Table 3.
Activation-induced immunologic pathways guided by H3K4me2 dominance at rest in naïve CD4 T cells as reported by ImmuneMap.
| Pathway | Total Genes | H3K4me2 dominant genes | % population |
|---|---|---|---|
| IL21 | 34 | 13 | 38.24% |
| 4-1BB | 29 | 9 | 31.03% |
| TNF superfamily pathway | 71 | 19 | 26.76% |
| GITR | 27 | 7 | 25.93% |
| CD40 | 48 | 12 | 25.00% |
| NFKB pathway | 84 | 20 | 23.81% |
| IL4 | 56 | 13 | 23.21% |
| IL1R1 | 55 | 12 | 21.82% |
| TLR signaling | 102 | 22 | 21.57% |
| IL6 | 44 | 9 | 20.45% |
| MAPK | 174 | 35 | 20.11% |
| IL17 | 50 | 10 | 20.00% |
| IL12 | 83 | 16 | 19.28% |
| Vitamin D | 90 | 17 | 18.89% |
| IL2 | 48 | 9 | 18.75% |
| General JAK / STAT | 155 | 29 | 18.71% |
| OX40 | 55 | 9 | 16.36% |
| Innate immunity signaling | 136 | 22 | 16.18% |
| TCR signaling | 92 | 14 | 15.22% |
| CTLA4 | 66 | 10 | 15.15% |