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. Author manuscript; available in PMC: 2016 Jul 22.

Published in final edited form as: Ther Drug Monit. 2016 Jan 21:10.1097/FTD.0000000000000275. doi: 10.1097/FTD.0000000000000275

Table 2.

Sirolimus Dose and Population Pharmacokinetic Parameter Estimates

Population Results
	Mean (SD)	Median (range)	Interquartile range
Clearance (L/hr)	11.8 (4.6)	11.6 (2.2–24.1)	8.5–14.4
Clearance (L/hr/70kg)	23.7 (6.7)	23.2 (8.4–48.8)	20.0–27.0
Clearance (L/hr/pop median wt)	9.9 (2.8)	9.7 (3.5–20.3)	8.4–11.3
Clearance (L/hr/1.85m²)	21.9 (5.4)	22.2 (8.1–37.7)	18.5–24.7
Therapeutic Dose (mg/m²/dose)	2.0 (0.7)	1.9 (0.77–3.9)	1.52–2.41
Therapeutic Dose (mg/kg/dose)	0.08 (0.04)	0.07 (0.02–0.19)	0.06–0.09
Therapeutic dose ((mg/kg)^0.75)	0.14 (0.05)	0.13 (0.06–0.29)	0.11–0.16