Table 1.
Baseline characteristic for African-American treatment naive participants by treatment group (N=1,131)
| Chlorthalidone | Lisinopril | Amlodipine | Doxazosin | p-value | ||
|---|---|---|---|---|---|---|
| Sample size (n,%) | 412 (36.4) | 240 (21.2) | 225 (19.9) | 254 (22.5) | ||
| AT BASELINE | ||||||
| Age, mean (SD) | 66.7 (8.7) | 65.0 (8.1) | 65.0 (7.5) | 65.4 (8.1) | 0.02 | |
| Women, n (%) | 191 (46.4) | 128 (53.3) | 111 (49.3) | 127 (50) | 0.39 | |
| SBP in mmHg, mean (SD) | 156.9 (12.2) | 157.1 (13.4) | 157.6 (12.9) | 157.2 (13.2) | 0.93 | |
| DBP in mmHg, mean (SD) | 90.7 (9.6) | 91.0 (9.3) | 90.9 (10.1) | 91.0 (9.5) | 0.98 | |
| Eligibility risk factors: | ||||||
| BMI, mean (SD), kg/m2 | 29.1 (6.4) | 30.1 (7.7) | 29.5 (6.1) | 29.2 (5.8) | 0.22 | |
| Type 2 diabetes, n (%) | 117 (28.4) | 57 (23.8) | 62 (27.6) | 74 (29.1) | 0.53 | |
| Current cigarette smoker, n (%) | 149 (36.2) | 91 (37.9) | 83 (36.9) | 86 (33.9) | 0.95 | |
| HDL cholesterol <35 mg/dL, n (%) | 16 (3.9) | 14 (5.8) | 9 (4.0) | 7 (2.8) | 0.38 | |
| LVH by electrocardiogram, n (%) | 133 (32.3) | 62 (25.8) | 64 (28.4) | 63 (24.8) | 0.14 | |
| Fasting glucose, mg/dL | 125.0 (72.2) | 120.1 (60.3) | 114.6 (49.0) | 124.1 (64.7) | 0.41 | |
| Total cholesterol, mg/dL | 218.9 (50.2) | 218.6 (44.2) | 216.5 (47.0) | 215.9 (41.8) | 0.84 | |
| HDL cholesterol, mg/dL | 52.9 (16.0) | 51.5 (17.4) | 52.2 (14.4) | 52.7 (16.2) | 0.75 | |
| LDL cholesterol, mg/dL | 139.9 (45.4) | 140.5 (39.1) | 139.6 (42.2) | 138.8 (38.0) | 0.98 | |
| Fasting triglyceride, mg/dL | 127.6 (88.3) | 135.2 (134.2) | 112.9 (69.7) | 126.4 (78.2) | 0.20 | |
| Glomerular filtration rate, mean (SD), mL/min/1.73 m2 | 83.4 (22.2) | 86.2 (20.8) | 87.8 (22.2) | 85.4 (19.5) | 0.09 | |
| AT 6 MONTH VISIT | ||||||
| SBP in mmHg, mean (SD) | 137.1 (16.2) | 141.0 (17.7) | 141.0 (15.9) | 142.3 (16.9) | 0.0003 | |
| DBP in mmHg, mean (SD) | 81.2 (10.7) | 82.8 (10.4) | 82.1 (10.0) | 82.7 (11.3) | 0.18 | |
| Adherence percentage, mean (SD) | 69.0 (29.5) | 65.0 (8.1) | 68.3 (27.7) | 64.3 (30.6) | 0.20 | |
SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; LVH, left ventricular hypertrophy.
*
test of differences between treatment groups: ANOVA for continuous variables, chi-square for categorical variables.