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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Addict Biol. 2016 Jan 20;22(3):766–778. doi: 10.1111/adb.12369

Figure 7.

Figure 7

Summary of eCB/CB1 and ethanol interactions on GABA release in the BLA. CB1 activation impairs the ethanol response, but the effects of ethanol and a CB1 antagonist are additive. A: Bar graphs plotting sIPSC frequencies of EtOH alone (44 mM; normalized to the pre-ethanol baseline; from Fig. 2B), EtOH in the presence of WIN (2 μM; normalized to WIN alone), and EtOH in the presence of AM251 (2 μM; normalized to AM251 alone) in naive and CIE rats. WIN-induced activation of CB1 impairs the effects of EtOH on BLA GABA release (main effect: ^^p<0.01 by two-way ANOVA). In contrast, CB1 antagonism and ethanol act independently to increase spontaneous GABA release (p>0.05 two-way ANOVA). B: Bar graphs plotting mIPSC frequencies of EtOH alone (from Fig. 2D), EtOH in the presence of WIN, and EtOH in the presence of AM251 in naive and CIE rats. CB1 agonism and antagonism do not affect EtOH facilitation of action potential-independent GABA transmission (p>0.05 two-way ANOVA).