Table 2.
Univariate hazard ratios for all-cause graft loss after transplant
| HIV+ | HIV− | |||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Recipient characteristics | ||||
| Age ≥ 50 yr | 1.22 (0.97–1.53) | 0.08 | 1.44 (1.40–1.49) | <0.001 |
| Male | 1.30 (0.88–1.92) | 0.20 | 1.15 (1.12–1.18) | <0.001 |
| African-American race | 1.46 (1.04–2.04) | 0.03 | 1.26 (1.21–1.32) | <0.001 |
| BMI (kg/m2) | 1.00 (0.97–1.03) | 0.97 | 1.01 (1.01–1.02) | <0.001 |
| HLA mismatch > 3 | 1.94 (1.31–2.87) | 0.001 | 1.21 (1.17–1.25) | <0.001 |
| PRA >80% | 1.33 (0.79–2.22) | 0.28 | 1.06 (1.01–1.10) | 0.01 |
| HCV infection | 2.22 (1.58–3.14) | <0.001 | 1.48 (1.40–1.57) | <0.001 |
| Diabetes | 1.15 (0.80–1.65) | 0.44 | 1.54 (1.49–1.58) | <0.001 |
| Time on dialysis (yrs) | 1.02 (0.98–1.07) | 0.34 | 1.03 (1.03–1.04) | <0.001 |
| Previous transplant | 1.24 (0.62–2.46) | 0.38 | 0.99 (0.95–1.03) | 0.68 |
| Donor characteristics | ||||
| Age ≥ 50 yr | 1.20 (0.92–1.56) | 0.18 | 1.61 (1.55–1.66) | <0.001 |
| African-American | 1.01 (0.67–1.53) | 0.95 | 1.22 (1.17–1.26) | <0.001 |
| HCV+* | 1.01 (0.61–1.66) | 0.97 | 1.32 (1.20–1.46) | <0.001 |
| KDPI ≥ 85 | 1.93 (1.16–3.14) | 0.01 | 1.87(1.80–1.95) | <0.001 |
| KDPI | 1.01 (1.00–1.02) | 0.04 | 1.01 (1.01–1.02) | <0.001 |
| CIT (hr) | 0.99 (0.99–1.02) | 0.82 | 1.01 (1.00–1.01) | 0.001 |
| CIT ≥ 12 | 1.26 (0.79–2.00) | 0.34 | 1.13 (1.08–1.19) | <0.001 |
| DGF | 1.84 (1.35–2.51) | <0.001 | 1.91 (1.84–1.98) | <0.001 |
*
Among HCV+ recipients only
BMI, body mass index; CIT, cold ischemia time; DGF, delayed graft function; HCV, hepatitis C virus; HIV, human immunodeficiency virus; HLA, human leukocyte antigen; HR, hazard ratio; IQR, interquartile range; KDPI, Kidney Donor Profile Index; PRA, panel-reactive antibody.