Table 3.
Modification of the effect of recipient HIV status on likelihood of graft loss by recipient and donor characteristics (adjusted)
| RECIPIENT FACTORS | HIV+ | HIV− | HR within strata | ||
|---|---|---|---|---|---|
|
| |||||
| N with/without graft loss | N with/without graft loss | ||||
| HR (95% CI) | HR (95% CI) | ||||
| HCV− A | 102/272 | 1.21 (0.92, 1.60) | 22,222/53,267 | Ref | 1.21 (0.92, 1.60) |
| HCV+ | 69/65 | 2.72 (1.75, 4.22) | 1,950/2,742 | 1.33 (1.26, 1.41) | 2.04 (1.32, 3.16) |
| HCV+*HIV+ | 1.68 (1.19, 2.36) | P=0.003 | |||
|
| |||||
| AP | 0.43 (0.23, 0.63) | RERI | 1.17 (0.15, 2.19) | p=0.02 | |
|
| |||||
| HLA mismatch ≤3 A | 27/81 | 0.91 (0.58, 1.43) | 7,021/17,444 | Ref | 0.91 (0.58, 1.43) |
| HLA mismatch >3 | 151/267 | 1.80 (1.31, 2.47) | 17,900/39,871 | 1.13 (1.10, 1.17) | 1.59 (1.15, 2.19) |
| HIV+*HLA>3 | 1.74 (1.15, 2.65) | ||||
|
| |||||
| AP | 0.42 (0.24, 0.60) | RERI | 0.75 (0.22, 1.28) | p=0.01 | |
|
| |||||
| DONOR FACTORS | |||||
| Age < 50B | 128/266 | 1.64 (1.20, 2.24) | 14,471/42,041 | Ref | 1.64 (1.20, 2.24) |
| Age ≥ 50 | 50/82 | 1.66 (1.07, 2.57) | 9,450/15,274 | 1.50 (1.45, 1.55) | 1.11 (0.72, 1.70) |
| HIV+*Age≥ 50 | 0.68 (0.49, 0.94) | ||||
|
| |||||
| AP | −0.29 (−0.71, 0.14) | RERI | −0.48 (−1.02, 0.07) | p=0.09 | |
|
| |||||
| Non-AAB | 153/292 | 1.52 (1.13, 2.05) | 21,032/49,513 | Ref | 1.52 (1.13, 2.05) |
| African-American | 25/56 | 1.36 (0.74, 2.53) | 3,889/7,802 | 1.20 (1.13, 2.14) | 1.14 (0.62, 2.11) |
| HIV+*AA Race | 0.75 (0.47, 1.19) | ||||
|
| |||||
| AP | −0.26 (−0.88, 0.36) | RERI | −0.35 (−0.98, 0.27) | p=0.27 | |
|
| |||||
| KDPI < 85 A | 186/459 | 1.46 (1.11, 1.91) | 30,545/92,514 | Ref | 1.46 (1.11, 1.91) |
| KDPI ≥85 | 32/26 | 2.31 (1.12, 4.76) | 4,369/5,345 | 1.65 (1.58, 1.73) | 1.40 (0.68, 2.86) |
| HIV+*KDPI≥85 | 0.96 (0.53, 1.72) | ||||
|
| |||||
| AP | 0.08 (−0.48, 0.65) | RERI | 0.20 (−1.25, 1.64) | p=0.79 | |
|
| |||||
| CIT <12 hrs A | 67/200 | 1.31 (0.93, 1.84) | 46,163/12,330 | Ref | 1.31 (0.93, 1.84) |
| CIT≥12 hrs | 134/256 | 1.64 (1.12, 2.41) | 18,300/41,162 | 1.10 (1.06, 1.16) | 1.49 (1.01, 2.18) |
| HIV+*CIT≥12 | 1.14 (0.70, 1.84) | ||||
|
| |||||
| AP | 0.14 (−0.23, 0.51) | RERI | 0.23 (−0.50, 0.96) | p=0.54 | |
A
adjusted for recipient age, race, HCV status, HLA mismatches, PRA, diabetes, CIT, and KDPI
B
adjusted for recipient age, race, HCV status, HLA mismatches, PRA, diabetes, donor age, and donor race
AA, African-American; AP, attributable proportion; CIT, cold ischemia time; HCV, hepatitis C virus; HIV, human immunodeficiency virus; HLA, human leukocyte antigen; HR, hazard ratio; KDPI, Kidney Donor Profile Index; PRA, panel-reactive antibody; RERI, relative excess risk due to interaction.