Figure 7.

Comparison between the Structures of DCB^{(Δ51–71) BIG1} and DCB-HUS Sec7

(A) Ribbon diagrams of the DCB^Δ51–71/DCB^Δ51–71′ dimer from human BIG1 (green) and the structure of the DCB-HUS region from Thielavia terrestris Sec7 (blue, PDB: ID 5HAS).

(B) Two views of an alignment of human BIG1 DCB^Δ51–71 and the DCB domain from the DCB-HUS T. terrestris Sec7 structure, with coloring as in (A). The root-mean-square deviation is 8.4 Å, with this relatively high value primarily reflecting differences in the conformation of the loop between α helices 4 and 5 and in the tilt of α helix 8.