Figure 1.

NFIB Accelerates Tumor Initiation and Progression in a Mouse Model of SCLC

(A) Schematic representation of the switched targeted transgene and measurements of luciferase activity from thorax over time following viral induction.

(B) Time point (in days) at which linear growth switched to exponential growth based on luciferase signal.

(C) Survival curves of animals within the four cohorts.

(D) Quantification of lesions (initial and advanced) at 70, 98, and 140 days following viral induction.

(E) A representative H&E staining of advanced lung lesions (taken from the control cohort, 193 days post-induction).

(F) Synaptophysin (SYN) staining of the same lung as in (E).

Error bars in (B) and (D) represent mean ± SEM.

See also Figures S1, S2, and S3.