Figure 2.

NFIB Is Associated with Increased Chromosomal Instability

(A and B) Copy number of Nfib (A) and Mycl (B) genomic locus in control, Mycl, and Nfib cohort tumors. The dotted line indicates the threshold.

(C and D) Genomic rearrangement and copy-number alterations on chromosome 4 in control (C) and Nfib (D) tumors. Line coloring indicates orientation of fusion ends.

(E and F) Total number of copy-number aberration (CNA) events on chromosome 4 (E) and in the whole genome (F) in different tumor classes (indicated by ^∗). Copy-number gain (log2 ratio > 0.459) and loss (log2 ratio < −0.67).

Data are mean ± SEM.