Table 2.
Functional annotation of the significant SNPs of the meta-analysis.
| SNP | Chromosome | Position | P-value | Gene | Impact | Global Freq | EUR Freq |
|---|---|---|---|---|---|---|---|
| rs1866863 | 6 | 13336583 | 3.23E-07 | TBC1D7 | Regulatory region | A:0.4583 | G:0.3907 |
| rs2705462 | 4 | 155648650 | 1.44E-06 | GUCY1A3 | Intergenic | T:0.2041 | T:0.2893 |
| rs2458304 | 6 | 13323663 | 2.54E-06 | TBC1D7 | Intron | A:0.4287 | G:0.3598 |
| rs17561798 | 4 | 98314790 | 9.89E-06 | RAP1GDS1 | Intron | G:0.0110 | G:0.0398 |
| rs1650137 | 12 | 104586532 | 1.76E-05 | CHST11 | Intron | A:0.2911 | A:0.2038 |
| rs2246417 | 21 | 45339588 | 1.95E-05 | LINC00316 | Intron | C:0.2428 | C:0.1461 |
| rs9319159 | 13 | 85445305 | 3.77E-05 | LINC00351 | Intron | T:0.3259 | T:0.3797 |
| rs13244651 | 7 | 10308596 | 4.11E-05 | Intergenic | Intergenic | G:0.3724 | G:0.4066 |
| rs1007021 | 9 | 2723657 | 4.38E-05 | KCNV2 | Intron | A:0.1388 | A:0.0696 |
| rs7858600 | 9 | 102764080 | 5.30E-05 | Intergenic | Intergenic | G:0.3694 | A:0.4861 |
| rs7336083 | 13 | 85429252 | 6.88E-05 | LINC00351 | Intron | A:0.3311 | A:0.3668 |
| rs17531553 | 7 | 10311703 | 7.08E-05 | Intergenic | Intergenic | G:0.3746 | G:0.4066 |
| rs1896373 | 10 | 52334599 | 7.46E-05 | Intergenic | Regulatory region | T:0.4994 | T:0.4513 |
| rs1007022 | 9 | 2723761 | 7.68E-05 | KCNV2 | Intron | A:0.0649 | A:0.0567 |
| rs11716445 | 3 | 49368662 | 8.01E-05 | RHOA | Intron | A:0.03115 | A:0.1024 |
| rs477897 | 4 | 168177763 | 8.65E-05 | ANXA10 | Intron | G:0.1148 | G:0.2256 |
| rs4789936 | 17 | 78901892 | 8.92E-05 | CEP295NL | Intron | T:0.4407 | T:0.5219 |
| rs2285084 | 4 | 2904558 | 1.00E-04 | ADD1 | Intron | G:0.2414 | G:0.2087 |
| rs7203818 | 16 | 49610387 | 1.01E-04 | ZNF423 | Intron | A:0.2169 | A:0.1581 |
Here we present the genes in which the SNPs are located, along with the frequency of the alleles in global and european populations, according to 1000 Genomes.