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. 2016 Jul 22;8:19. doi: 10.3389/fnsyn.2016.00019

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Copyright © 2016 Li and Blanpied.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nanoscale regional density of PSD-95 within the synapse correlates with probe diffusion coefficient. (A) Typical example of tracks and PSD-95 positions. Tracks pseudo-colored purple, PSD-95 positions pseudo-colored by regional density. (B) Cumulative frequency distributions of probe D_eff binned in increasing regional densites of PSD-95 surrounding the subtracks (n = 448 subtracks in 0–5 PSD-95, 281 in 5–10, 159 in 10–15, 106 in 15–20, 59 in 20–25, 22 in 25–30, 24 in 30+). (C) PSD-95 regional density and the median D_eff of the binding probe; relationship tested by linear regression.