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. 2016 Jul 19;9(7):e002636. doi: 10.1161/CIRCHEARTFAILURE.115.002636

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© 2016 The Authors.

Circulation: Heart Failure is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Skinned cardiomyocytes. A and B, Right ventricular (RV) cardiomyocyte stiffness was gradually increased in mild and severe RV dysfunction in comparison to control. C and D, Protein kinase A (PKA) incubation significantly decreased cardiomyocyte stiffness in mild and severe RV dysfunction but remained significantly elevated in comparison to controls. Data are presented as mean±SEM. Controls: n=5, mild RV dysfunction: n=5, and severe RV dysfunction: n=5. **P<0.01, ***P<0.001 vs control. The P_interaction value represents the response of passive tension on increase in sarcomere length or PKA incubation.