Fig. 3.

Trajectories of fasting plasma glucose, total cholesterol, HDL cholesterol, and predicted 10-year CVD risk. HDL cholesterol, high-density lipoprotein cholesterol; ACC/AHA, American College of Cardiology/American Heart Association; CVD: cardiovascular disease. Trajectories for risk factors during 15 years of follow-up until diagnosis of CVD, death or censoring from the study. The figures represent a hypothetical man of 65 years, on lipid- or glucose-lowering treatment. Light blue “stable weight” (including 87.8 % of CVD patients); dark blue “progressive weight loss” (including 5.8 % of CVD patients); red “progressive weight gain” (including 6.4 % of CVD patients); gray “CVD-free”; black “non-CVD mortality” groups. Similar trajectories for a hypothetical woman of 65 years of age are shown in Figure S2 in Supplementary Material. (Color figure online)