Table 2.

Major non-ADPKD renal cystic diseases

Disease	Cyst proliferation	Cyst distribution/size	Typical life stage for cyst diagnosis	Pathophysiological characteristics
Multiple simple renal cyst	Moderate	Size diversity/non-uniform distribution	All ages	Rare under age 30 years; manifestation increases with age
Acquired cystic disease of the kidney	Moderate to great	Diffusibility	Adulthood	Cyst formation precedes ESRD
Tuberous sclerosis	Moderate to great	Uniform distribution of relatively small (<1 to 2 cm) cysts	All ages	Renal angiomyolipomas, skin lesions, periungual fibromas, retinal hamartomas, and cardiac rhabdomyomas
ARPKD	Great	Diffusibility/small cysts	Birth	Greatly enlarged kidney, congenital hepatic fibrosis