Table 5. Stepwise linear regression analysis for key variables included in Fig. 2.
| Dependent variables: | pAMPK α1/α2 | PgC1 α | Ppar α | Ppar γ | AMPK α1 expr. | UCB | UGT1A1 genotype | BMI | LBM | T3 |
|---|---|---|---|---|---|---|---|---|---|---|
| pAMPK α1/α2 | 0.190 (0.000) | |||||||||
| PgC 1α | 0.070 GS (0.006) | 0.743 (0.000) | 0.781 (+Ppar α) (0.000) | 0.060 (0.041) | 0.083 GS (0.020) | |||||
| Ppar α | 0.743 (0.000) | 0.771 (+PgC1 α) (0.000) | ||||||||
| Ppar γ | 0.496 (0.000) | |||||||||
| AMPK α1 expr. | ||||||||||
| BMI | 0.072 (0.004) | |||||||||
| LBM | 0.483 (0.000) | 0.538 (+BMI) (0.000) | ||||||||
| Sirt-1 | 0.069 (0.009) |
Corrected R2 coefficients and corresponding p-values (in brackets) from stepwise linear regression analysis are provided.
Unspecified regressions are valid for the entire study population. Ceffect valid for control subjects only; GSeffect valid for GS subjects only.
Abbreviations: pAMPK α1/α2: Phosphorylated 5′-AMP activated kinase; PgC 1α: Peroxisome proliferator-activated receptor c coactivator 1; pPpar α: Phosphorylated peroxisome proliferator activated receptor alpha; Ppar γ: Phosphorylated peroxisome proliferator activated receptor gamma; AMPK α1 expr.: AMPK α1 gene expression; UCB: unconjugated bilirubin; UGT1A1: UDP glucuronosyltransferase 1A1 polymorphism; BMI: Body mass index; LBM: Lean body mass; Sirt-1: Sirtuin-1; T3: Free triiodothyronine.
Included variables:
pAMPK α1/α2: AMPK1a expr., PgC1 α, pPpar α, pPpar γ, TChol, TG, UCB, UGT1A1 genotype, BMI, LBM, LDL/HDL, TSH, T3, T4.
PgC 1 α: pAMPK α1/α2, AMPK1a expr., Ppar α, Ppar γ, TChol, TG, UCB, UGT1A1 genotype, BMI, LBM, LDL/HDL, TSH, T3, T4.
pPpar α: pAMPK α1/α2, AMPK1a expr., Ppar γ, TChol, TG, UCB, UGT1A1 genotype, BMI, LBM, LDL/HDL, TSH, T3, T4.
AMPK α1 expr.: pAMPK α1/α2, Ppar α, Ppar γ, TChol, TG, UCB, UGT1A1 genotype, BMI, LBM, LDL/HDL, TSH, T3, T4.
BMI: AMPK α1 expr., pAMPK α1/α2, PgC1 α, Ppar α, Ppar γ, UCB, UGT1A1 genotype, LBM, TSH, T3, T4.
LBM: AMPK α1 expr., pAMPK α1/α2, PgC1 α, Ppar α, Ppar γ, UCB, UGT1A1 genotype, BMI, TSH, T3, T4.
Sirt-1: AMPK α1 expr., pAMPK α1/α2, PgC1 α, Ppar α, Ppar γ, UCB, UGT1A1 genotype, BMI, LBM, TSH, T3, T4, FGF21, TChol, TG, LDL/HDL.
(In further analyses the variables age, gender and those specifying lifestyle were included, however these procedures did not significantly change the models’ outcome).