Table 6. Stepwise linear regression analysis with reference to metabolic pathways (Fig. 2).
Dependent variables: | C-Peptide | Glucose | TChol | TG | UCB | pPpar γ | LBM | BMI |
---|---|---|---|---|---|---|---|---|
HbA1c | 0.314 (0.000) | 0.340 (+Glucose) (0.000) | ||||||
C-Peptide | 0.575 (+TG, BMI) (0.000) | 0.447 (0.000) | 0.544 (+TG) (0.000) | |||||
Insulin | 0.350 (0.000) | 0.415 (+TG) (0.000) | ||||||
Glucose | 0.264 (0.000) | |||||||
TChol | 0.158 (0.000) | 0.205 (+TG) (0.000) | ||||||
HDL | 0.187 (0.000) | |||||||
LDL | 0.198 (0.000) | 0.226 (+TG) (0.000) | ||||||
TG | 0.318 (+BMI) (0.000) | 0.249 (0.000) | ||||||
Apo A1 | 0.190 (+BMI) (0.000) | 0.047 (0.018) | ||||||
Apo B | 0.274 (0.000) | 0.303 (+TG) (0.000) | ||||||
LPA2 | 0.034 (0.043) |
Corrected R2 coefficients and p-values (in brackets) from stepwise linear regression analysis, involving the entire study population, are provided.
HbA1c: Glycated haemoglobin A1c; pPpar γ: Phosphorylated peroxisome proliferator activated receptor gamma; T3: Free triiodothyronine; T4: Free thyroxine; BMI: Body mass index; LBM: Lean body mass; TChol: Total cholesterol; HDL: High density lipoprotein cholesterol; LDL: Low density lipoprotein cholesterol; TG: Triglyceride; LPA2: Lipoprotein A2; ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B.
Included variables:
HbA1c: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, PgC1 α, pPpar α, pPparγ, AMPK α1 expr., BMI, LBM, TG, FGF-21, C-Peptide, Glucose.
C-Peptide/Insulin: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21, Glucose, HbA1c.
Glucose: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21, C-Peptide, TChol, LDL/HDL.
TChol: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.
HDL: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1expr., BMI, LBM, TG, FGF-21.
LDL: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.
TG: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21, TChol, Glucose, HbA1c.
Apo A1: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.
Apo B: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.
LPA2: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.
(In further analyses the variables age, gender and those specifying lifestyle were included, however these procedures did not significantly change the models’ outcome).