Table 6. Stepwise linear regression analysis with reference to metabolic pathways (Fig. 2).

Dependent variables:	C-Peptide	Glucose	TChol	TG	UCB	pPpar γ	LBM	BMI
HbA1c		0.314 (0.000)				0.340 (+Glucose) (0.000)
C-Peptide		0.575 (+TG, BMI) (0.000)		0.447 (0.000)				0.544 (+TG) (0.000)
Insulin				0.350 (0.000)				0.415 (+TG) (0.000)
Glucose	0.264 (0.000)
TChol				0.158 (0.000)			0.205 (+TG) (0.000)
HDL				0.187 (0.000)
LDL				0.198 (0.000)				0.226 (+TG) (0.000)
TG			0.318 (+BMI) (0.000)					0.249 (0.000)
Apo A1							0.190 (+BMI) (0.000)	0.047 (0.018)
Apo B				0.274 (0.000)				0.303 (+TG) (0.000)
LPA2					0.034 (0.043)

Corrected R² coefficients and p-values (in brackets) from stepwise linear regression analysis, involving the entire study population, are provided.

HbA1c: Glycated haemoglobin A1c; pPpar γ: Phosphorylated peroxisome proliferator activated receptor gamma; T3: Free triiodothyronine; T4: Free thyroxine; BMI: Body mass index; LBM: Lean body mass; TChol: Total cholesterol; HDL: High density lipoprotein cholesterol; LDL: Low density lipoprotein cholesterol; TG: Triglyceride; LPA2: Lipoprotein A2; ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B.

Included variables:

HbA1c: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, PgC1 α, pPpar α, pPparγ, AMPK α1 expr., BMI, LBM, TG, FGF-21, C-Peptide, Glucose.

C-Peptide/Insulin: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21, Glucose, HbA1c.

Glucose: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21, C-Peptide, TChol, LDL/HDL.

TChol: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.

HDL: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1expr., BMI, LBM, TG, FGF-21.

LDL: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.

TG: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21, TChol, Glucose, HbA1c.

Apo A1: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.

Apo B: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.

LPA2: UCB, TSH, T3, T4, UGT1A1-genotype, pAMPK α1/α2, pPpar α, pPpar γ, PgC1 α, AMPK α1 expr., BMI, LBM, TG, FGF-21.

(In further analyses the variables age, gender and those specifying lifestyle were included, however these procedures did not significantly change the models’ outcome).