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. 2016 Mar 28;20(8):1427–1442. doi: 10.1111/jcmm.12832

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© 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The effects of X22 on bodyweight, blood glucose and blood lipid profile in HFD rats. Male rats weighing 360–370 g were first fed either a normal diet (Ctrl) or high‐fat diet (HFD) for 8 weeks. The HFD rats were subsequently split into two groups, one group treated with X22 (20 mg/kg) for 4 weeks and the other group with vehicle control (n = 7 in each group). The bodyweight and blood glucose were monitored weekly. At the end of experiment, the rats were killed, the blood samples were collected and centrifuged, and serum was isolated. (A) The bodyweight. (B) The serum glucose level. (C–E) The serum lipid profile, including triglycerides (TG), total cholesterol (TCH), low‐density lipoprotein (LDL) (*P < 0.05, **P < 0.01, n = 7 in each group).