Table 1.
Changes of heart rate, PR interval, QRS duration and QT interval following myocardial ischaemia and reperfusion
| Rac1f/f | Rac1f/f+NSC23766 | Rac1ckd | P value | |
|---|---|---|---|---|
| Mouse numbers | 10 | 7 | 13 | |
| Heart rate, bpm | ||||
| Basal | 346 ± 20 | 332 ± 14 | 343 ± 24 | 0.917 |
| Ischaemia | 345 ± 20 | 352 ± 11 | 343 ± 18 | 0.946 |
| Reperfusion | 340 ± 18 | 359 ± 16 | 313 ± 15 | 0.173 |
| PR interval, ms | ||||
| Basal | 40.9 ± 0.8 | 41.4 ± 1.9 | 44.4 ± 1.0 | 0.798 |
| Ischaemia | 43.1 ± 3.6 | 45.1 ± 3.2 | 43.8 ± 4.2 | 0.239 |
| Reperfusion | 42.3 ± 1.5 | 51.2 ± 5.7 | 44.9 ± 1.7 | 0.958 |
| QRS duration, ms | ||||
| Basal | 21.3 ± 1.3 | 18.6 ± 2.1 | 21.6 ± 1.6 | 0.661 |
| Ischaemia | 22.6 ± 0.9 | 19.8 ± 1.4 | 21.3 ± 1.1 | 0.656 |
| Reperfusion | 21.4 ± 0.9 | 20.7 ± 1.1 | 22.1 ± 2.4 | 0.958 |
| QTc interval, ms | ||||
| Basal | 72.0 ± 1.9 | 64.9 ± 4.4 | 63.7 ± 3.3 | 0.264 |
| Ischaemia | 75.6 ± 1.6 | 68.5 ± 4.3 | 69.2 ± 3.3 | 0.250 |
| Reperfusion | 76.1 ± 2.0 | 74.2 ± 2.3 | 71.0 ± 2.2 | 0.230 |
Data are mean ± SEM. Mice were anaesthetized with ketamine and xylazine, and artificially ventilated with a respirator. Heart rate‐corrected QT interval (QTc) was calculated according to the formula QTc = QT/(RR/100)1/2. P values were analysed by one way anova. No significant difference was found in any of the parameters among three groups of mice.