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. 2016 May 23;291(30):15602–15613. doi: 10.1074/jbc.M116.734657

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Transmission electron microscopy of Pla2g2e^+/+ and Pla2g2e^−/− skins. A, toluidine blue staining of Pla2g2e^+/+ and Pla2g2e^−/− skins. Boxed areas (panels a–d) are magnified in B. Bars, 100 μm. B, transmission electron microscopy of hair follicles in Pla2g2e^+/+ (panels a and b) and Pla2g2e^−/− (panels c and d) skins. Locations of ORS, IRS, cuticle (Cu), and cortex (Cx) are indicated by yellow arrows. Red arrows indicate abnormal features observed in Pla2g2e^−/− mice (formation of cytoplasmic cysts and pyknotic nuclei in the IRS and the presence of pericuticular cells). In addition, the cuticle and cortex were unusually dissociated in Pla2g2e^−/− mice. Bars, 10 μm.