FIGURE 1.

Alignment of N terminus and TM-1 residues of connexin isoforms that exhibit different gap junctional voltage dependence. Sequence alignments are displayed from connexins showing less (zfCx35, bottom) to more voltage dependence (mCx37, top). Basic and acidic residues are depicted in blue and red, respectively. Cx26, Cx42, Cx46, and Cx50 utilized in this work are in red. Amino acids residues are numbered according to the Cx26 sequence. NT, N terminus; TM-1, transmembrane domain-1; ch, chicken; h, human; m, mouse; x, Xenopus; zf, zebrafish. The values of voltage dependence were taken from Ref. 17.