Figure 1. KXS₂₀₁₂ alleviates the depression-like symptoms in CMS-induced depressive rats.

The CMS-induced depressive rats were randomly divided into six groups: control, CMS model, imipramine (20 mg/kg/day), KXS₂₀₁₂ low dose (60.9 mg/kg/day), KXS₂₀₁₂ medium dose (182.7 mg/kg/day) and KXS₂₀₁₂ high dose (548.1 mg/kg/day). After drug treatment, sucrose preference (A), forced swimming (B) and open field tests (C) were carried out, as described in the method session. Values are expressed in percentage of un-stressed control, second (s), number or miter (m), Mean ± SEM, n = 8, *p < 0.05, **p < 0.01 and ***p < 0.001 compared to the control.