Table 1. Summary table of binding affinities between various CagA constructs and PAR1b.
| GST-CagA constructs | Type of CM motif | CM sequence | No. of CM motifs | PAR1b binding | KD ± SE (nM) |
|---|---|---|---|---|---|
| ∆CM | — | — | 0 | N | ND |
| 1CMW1 | Western | FPLKRHDKVDDLSKVG | 1 | Y | 90.3 ± 14.1 |
| 2CMW | Western | FPLKRHDKVDDLSKVG | 2 | Y | 26.6 ± 3.7 |
| 4CMW | Western | FPLKRHDKVDDLSKVG | 4 | Y | 2.43 ± 0.45 |
| 1CMW2 | Western | FPLKRHDKVDDLSKVG | 1 | Y | 106 ± 19 |
| 1CME | East Asian | FPLRRSAAVNDLSKVG | 1 | Y | 46.4 ± 7.4 |
| 1CMAmI | Amerindian I | SSLKRHAKVDDLSKVG | 1 | N | ND |
| 1CMAmII | Amerindian II | YTLKMHAGDDNLRSKVG | 1 | N | ND |
ND: not determined.