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. 2016 Jul 22;6:30230. doi: 10.1038/srep30230

Figure 5. Protein-protein interaction (PPI) network of the down-regulated proteins in MRJP1 VSMC.

Figure 5

(a) Represents the PPI networks of the down-regulated proteins are visualized by GeneMANIA plugin within Cytoscape. Networks are all enabled and the top 50 related genes and at most 20 attributes were displayed via GO biological process-based weighting. The terms are shown as “glycosyl compound biosynthetic process,” “ATPase activity,” “mRNA splicing, via spliceosome” and “nucleic acid transport,” respectively. q values < 0.05 are considered to be significantly enriched. (b) The node proteins that linked the network with high degree of interaction and the ones in pathways of “Vascular smooth muscle contraction,” “TCA cycle,” “RNA splicing, via spliceosome” and “Nuclear transport” were highlighted by NetworkAnalyst online software (http://www.networkanalyst.ca). Enrichment pathways are considered to be significant when p values < 0.05. The green nodes in the network are the down-regulated proteins by the expression of MRJP1.