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. 2016 Jul 22;6:29820. doi: 10.1038/srep29820

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H9c2 cells were exposed to normoxia or hypoxia for 12 h with or without ZYZ-488 treatment. (A) Representative Western blot showed hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3 was inhibited by ZYZ-488. Bar graphs represent the quantitative difference in protein level of caspase-9 (B) and caspase-3 (C). ^###P < 0.001, ^#P < 0.05 versus control group. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001 versus vehicle group. Data are the mean ± S.E.M of results from at least three independent experiments.