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. 2016 Jul 22;6:29820. doi: 10.1038/srep29820

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(A) Apoptosis fraction of hypoxia-induced H9c2 cells were measured in presence or absence of ZYZ-488 treatment. (B) Percentage of apoptotic cardiomyocytes were analyzed. ^###P < 0.001 versus control group. Data are the mean ± S.E.M of results from at least three independent experiments. (C) Representative Western blot showed caspase-9 activity for control or Apaf-1 (siApaf-1) silencing in the presence or absence of ZYZ-488 treatment.