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. Author manuscript; available in PMC: 2017 Jul 19.
Published in final edited form as: Immunity. 2016 Jul 19;45(1):83–93. doi: 10.1016/j.immuni.2016.06.022

Figure 1. CD4+ T cell specific miR-17-92 deletion mice more effectively control experimental autoimmune encephalomyelitis (EAE).

Figure 1

(A) Wild type (WT) mice and those of a CD4+ specific miR-17-92 deletion strain (mir17-92Flox/Flox/CD4-Cre+, or “mir17-92−/−“) were injected s.c. with 100 μg MOG 35–55 in CFA and 250ng Pertussis Toxin i.p. Disease severity was scored daily. Mean scores for WT mice and mir17-92−/− mice over time are represented (±SEM; p < 0.05, n = 7–10 per group). Shown are combined results of 3 individual experiments. (B and C) On day 45, CNS-infiltrating T cells were recovered and stained for IL-17, IFNγ. The mean percentage of CNS IL-17+CD4+ T cells on day 45 was determined. (D and E) CNS-infiltrating T cells were isolated on day 45 and the percentage of CD4+ T cells that were Foxp3+ was determined. C and E present the mean (± SEM; *p < 0.05) of at least 3 experiments, while B and D are representative analyses.