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. 2016 Jul 22;16:344. doi: 10.1186/s12879-016-1647-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Prevalence and cross-clade reactivity of anti-Tat antibodies. CART-naïve, chronically HIV-infected individuals (n = 96) were tested for the presence of anti-Tat antibodies by ELISA. a Percentage of subjects with anti-clade C Tat IgG, IgA or IgM or anti-clade C Tat negative. b Number of anti-clade C Tat positive individuals able to recognize clade B Tat. c Number of subjects able to recognize clade B but not clade C Tat. d Heatmap showing, for single donors, positivity (black) or negativity (grey) toward clade C or clade B Tat for each isotype after unsupervised clustering. e Venn diagram analyses of the number of subjects recognizing clade B and/or C Tat stratified by the antibody isotype displayed