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. 2016 Jul 22;17:50. doi: 10.1186/s12881-016-0312-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Ancestral pedigree depicting the relationship between three affected individuals. The common ancestor for three individuals homozygous (shaded symbols; designated with arrows) for the c.1624–11G>A mutation in ZAP70 is an individual who was born in 1816. Individuals heterozygous for c.1624–11G>A are depicted as half-shaded circles and squares, and consanguineous marriages are depicted by double solid lines. Open circles in the bottom generation represent individuals who do not carry the ZAP70 mutation. Not all individuals depicted were tested for the ZAP70 mutation