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. 2016 Jul 22;14:107. doi: 10.1186/s12916-016-0652-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Relationship between plasma P1-immunoglobulin (IgM) levels and non-alcoholic fatty liver disease (NAFLD) upon further characterization of liver biopsies. a IgM titers towards P1 in controls and patients with NAFLD grouped based on their ALT levels. b Plasma IgM antibody titers against the P1 mimotope in patients with NAFLD in which the liver biopsy was evaluated and scored as simple steatosis versus non-alcoholic steatohepatitis (NASH). Anti-P1 IgM titers after scoring liver biopsies for c steatosis, d inflammation, e hepatocyte ballooning, f applying the NAFLD activity score (NAS), and g scoring fibrosis. Data are expressed in relative light units (RLU)/100 ms and presented as means. **p < 0.01