Table 1.
Clinical and biological characteristics of patients with non-alcoholic steatohepatitis for antibody measurements
| Participant characteristics (mean ± SD) | |||
|---|---|---|---|
| Controls (n = 68) |
NAFLD (simple steatosis) (n = 18) |
NAFLD (NASH) (n = 53) |
|
| Male/female | 27/41 | 9/9 | 24/29 |
| Age (y) | 40.9 ± 12 | 45.7 ± 13 | 45.9 ± 10 |
| BMI (kg/m2) | 26.3 ± 4.9 | 33.6 ± 5.6 | 34.3 ± 4.7 |
| Waist circumference (cm) | 89.4 ± 13.7 | 108.5 ± 12.9 | 109.0 ± 14.3 |
| Triglycerides (mg/dL) | |||
| Median | 75 | 151 | 160 |
| Interquartile range | 48 | 66 | 118.5 |
| Cholesterol (mg/dL) | 181.33 ± 32.9 | 197.8 ± 53.2 | 196.2 ± 43.5 |
| HDL (mg/dL) | 54.8 ± 17.7 | 41.44 ± 8.0 | 42.87 ± 8.9 |
| LDL (mg/dL) | 105.65 ± 26.9 | 135.3 ± 47.2 | 122.9 ± 36.3 |
| Markers of inflammation and liver blood tests (mean (IQR)) | |||
| TNF-α (pg/ml) | 2.5 (0.7) | 3 (2.3) | 3 (1.9) |
| MCP-1 (pg/ml) | 96.9 (27) | 122.4 (24.05) | 120.1 (37.95) |
| IL-1β (pg/ml) | 0.42 (0.87) | 0.27 (0.36) | 0.17 (0.64) |
| IL-6 (pg/ml) | 13.2 (35.8) | 16.1 (8.1) | 24.5 (45.25) |
| IL-8 (pg/ml) | 5.4 (4) | 5.34 (3.5) | 7.7 (8.05) |
| γGT (IU/L) | - | 51.6 (22.7) | 55.6 (32) |
| Leptin | 11.1 (8.8) | 23.0 (15.8) | 30.5 (18.5) |
| AST (IU/L) | 21 (9) | 28 (11.8) | 49 (56.5) |
| ALT (IU/L) | 18 (8) | 38 (22.8) | 66 (99.5) |
| AST/ALT ratio | 1.3 (0.25) | 0.8 (0.2) | 0.8 (0.4) |
AST aspartate transaminase, ALT alanine transaminase, BMI body mass index, γGT gamma-glutamyltransferase, HDL high-density lipoprotein, IL interleukin, IQR interquartile range, LDL low-density lipoprotein, MCP-1 monocyte chemoattractant protein-1, NAFLD non-alcoholic fatty liver disease, NASH non-alcoholic steatohepatitis, TNF-α tumor necrosis factor alpha