Table 2.
Characteristics of intensive care unit patients without acute lung injury or acute respiratory distress syndrom included in randomized controlled trials
| Study | Country | Research period | Ventilation strategies | Patients (n) | Cause | Study quality assessment, Jadad scale | Results | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| PaO2/FIO2 | Lung compliance (ml/cmH2O) | Deaths (n) | Length of ICUstay (days) | Length of hospital stay (days) | |||||||
| Lee PC [24] 1990 | USA | 10/1987-02/1988 | A (lower VT + lower PEEP) vs B (higher VT + lower PEEP) | 103 | Multiple trauma or celiotomy | 5 | 294 ± 86/260 ± 78 | NR | NR | 4.6 ± 1/2.7 ± 0.5 | NR |
| Borges DL [25] 2013 | Brazil | 01/2011-03/2012 | A (lower VT + lower PEEP) vs C (lower VT + higher PEEP) | 89 | CABG surgery | 6 | 270 ± 90/328.25 ± 84.75 | 47.4 ± 12.5/55.8 ± 19.1 | NR | NR | NR |
| Dyhr T [26] 2002 | Denmark | NR | A (lower VT + lower PEEP) vs D (lower VT + ZEEP) | 15 | CABG surgery | 7 | 379.5 ± 90/304.5 ± 97.5 | 58 ± 11/34 ± 10 | NR | NR | NR |
| Chaney MA [27] 2000 | America | NR | B (higher VT + lower PEEP) vs A (lower VT + lower PEEP) | 25 | CABG surgery | 5 | 368.6 ± 93.6/395.1 ± 179.6 | 58 ± 11.4/48.2 ± 23 | NR | NR | NR |
| Wrigge H [28] 2005 | Germany | NR | B (higher VT + lower PEEP) vs C (lower VT + higher PEEP) | 44 | CABG surgery | 6 | NR | NR | NR | 1.2 ± 0.5/ 2.1 ± 0.5 | NR |
| Koutsoukou A [29] 2006 | Greece | 2005 | D (lower VT+ ZEEP) vs A (lower VT + lower PEEP) | 21 | Severe brain damage | 6 | NR | NR | NR | NR | NR |
| Good JT Jr [30] 1979 | America | NR | B (higher VT + lower PEEP) vs E (higher VT + ZEEP) | 24 | Open heart surgery | 7 | NR | NR | NR | NR | NR |
| Marvel SL [31] 1986 | America | 1983 | E (higher VT + ZEEP) vs B (higher VT + lower PEEP) vs F (higher VT + higher PEEP) |
44 | CABG surgery | 7 | NR | NR | NR | NR | 8.9 ± 0.4/8.8 ± 0.5 |
| Zupancich E [32] 2005 | Italy | NR | B (higher VT + lower PEEP) vs C (lower VT + higher PEEP) | 40 | CABG surgery | 6 | 324 ± 120/344 ± 94 | NR | NR | NR | NR |
| Pinheiro deOliveira R [33] 2010 | Brazil | NR | B (higher VT + lower PEEP) vs A (lower VT + lower PEEP) | 20 | Surgery and trauma | 6 | 334.25 ± 82.3/299.5 ± 71.9 | NR | 4/3 | 6.5 ± 5/7.7 ± 7.6 | NR |
| Determann RM [4] 2010 | Netherlands | 01/2005-12/2007 | E (higher VT + ZEEP) vs D (lower VT+ ZEEP) | 150 | Neurosurgery/neurology, cardiothoracic surgery, and cardiology | 7 | NR | NR | 23/24 | NR | NR |
The ventilation strategies are described in “Table 1”. PaO2/FIO2 partial pressure of arterial oxygen/fraction of inspired oxygen, PEEP positive end-expiratory pressure, VT tidal volume, ZEEP zero end-expiratory pressure, NR no result reported, CABG coronary artery bypass graft