Table 4.
Cases of optic neuritis in IBD patients in the absence of anti-TNFα reported in the literature (n = 8)
| Case Sex/Age | References | Type/Duration/ Activity IBD | IS | Associated MS lesions | Initial VA/ RAPD/VEP | Therapy | Visual outcome | ON recurrence during F-U (mo) |
|---|---|---|---|---|---|---|---|---|
| 1 F/40 |
Ernst BB. Ophtalmology 1991 |
UC/17ys Quiescent | Ukn | No | 20/20 positive/ Ukn |
No | Total recovery | No (Ukn) |
| 2 F/25 |
Ernst BB. Ophtalmology 1991 |
CD/1y Quiescent |
Ukn | No | 20/25 positive/ Ukn |
Pulse MP | Total recovery | No (Ukn) |
| 3 M/U |
Felekis T. Inflam Bowel Dis 2009 |
CD/Ukn Ukn |
No | No | Ukn Ukn / Ukn |
Pulse MP | Ukn | Ukn |
| 4 F/38 |
Sedwick LA. Clin Neuro-ophtalmol 1984 |
UC/Ukn Quiescent |
No | No | Ukn Ukn / Ukn |
Oral prednisone | Total recovery | No (0.5) |
| 5 F/21 |
Sedwick LA. Clin Neuro-ophtalmol 1984 |
UC/12ys Quiescent | No | No | Finger count positive/ Ukn |
Oral prednisone | Color desaturation | No (Ukn) |
| 6 F/26 |
Sedwick LA. Clin Neuro-ophtalmol 1984 |
UC/9ys Active |
No | No | Loss of vision Ukn / Ukn |
Oral prednisone | Hands motions | No (1) |
| 7 F/36 |
Sedwick LA. Clin Neuro-ophtalmol 1984 |
UC/concomitant Active |
No | No | 20/30-15/20 Positive/ Ukn |
Oral prednisone | Total recovery | No (36) |
| 8 M/45 |
Van de Scheur MR. J Clin Gastroenterol 2002 |
CD/1y Quiescent | No | No | Ukn No/PL |
Oral prednisone | Stabilization | No (1) |
(CD = Crohn’s disease; F = female; F-U = follow-up; IBD = inflammatory bowel disease; IS = immunosuppressive therapy; M = male; Mo = months; MP = methylprednisolone; MS = multiple sclerosis; PL = prolonged latency; RAPD = relative afferent pupillary defect; Ukn = unknown; UC = ulcerative colitis; VA = visual acuity; VEP = visual evoked potential; Y(s) = year(s))