Table 2.
Bone microstructure in IBD patients assessed by high-resolution peripheral quantitative CT [HR-pQCT].
| IBD | CD | UC | CO | IBD vs CO | CD vs UC vs CO | CD vs CO | UC vs CO | |
|---|---|---|---|---|---|---|---|---|
| p | p-Value | p-Value | p-Value | |||||
| Bone geometry | ||||||||
| Total bone area [mm2] | 300 [257;373] | 293 [247;362] | 310 [261;376] | 310 [259;369] | 0.976 | 0.709 | - | - |
| Ct. area [mm2] | 54 [45;62] | 50 [39;60] | 57 [50;65] | 59 [54;75] | 0.001 | < 0.001 | < 0.001 | 0.174 |
| Tb. area [mm2] | 241 [198;300] | 241 [193;296] | 240 [201;302] | 229 [202;286] | 0.558 | 0.786 | - | - |
| Volumetric bone mineral density | ||||||||
| Total BMD [HA/ cm3] | 299 [251;335] | 286 [241;332] | 304 [285;344] | 326 [302;368] | 0.001 | < 0.001 | < 0.001 | 0.115 |
| Ct. BMD [HA/cm3] | 811 [771;851] | 803 [760;849] | 820 [783;853] | 868 [828;892] | < 0.001 | < 0.001 | < 0.001 | 0.003 |
| Tb. BMD [HA/cm3] | 163 [130;189] | 151 [122;188] | 170 [153;192] | 179 [147;208] | 0.034 | 0.022 | 0.008 | 0.477 |
| Tb. meta BMD [HA/ cm3] | 222 [191;246] | 212 [183;247] | 226 [210;246] | 241 [211;267] | 0.005 | 0.005 | 0.002 | 0.115 |
| Tb. inn BMD [HA/ cm3] | 124 [89;150] | 113 [81;148] | 131 [110;154] | 132 [100;173] | 0.097 | 0.047 | 0.022 | 0.782 |
| Bone microstructure | ||||||||
| BV/TV [%] | 13.6 [10.8;15.8] | 12.6 [10.2;15.7] | 14.2 [12.8;16.0] | 14.9 [12.3;17.4] | 0.033 | 0.022 | 0.008 | 0.469 |
| Tb. N [mm-1] | 2.00 [1.87;2.22] | 1.96 [1.81;2.22] | 2.01 [1.89;2.23] | 2.09 [1.93;2.24] | 0.118 | 0.216 | - | - |
| Tb. Th [µm] | 64 [59;75] | 63 [55;73] | 68 [62;78] | 68 [62;80] | 0.058 | 0.017 | 0.009 | 0.763 |
| Tb. Sp [µm] | 429 [376;481] | 443 [375;492] | 420 [376;456] | 402 [369;454] | 0.083 | 0.141 | - | - |
| Inhomogeneity [µm] | 175 [152;201] | 179 [151;207] | 173 [152;194] | 170 [144;190] | 0.118 | 0.193 | - | - |
| Ct. Th [µm] | 730 [595;815] | 690 [570;810] | 745 [650;840] | 830 [760;930] | < 0.001 | < 0.001 | < 0.001 | 0.015 |
| Ct. Pm [mm] | 74.1 [68.9;83.0] | 74.1 [66.2;81.7] | 76.9 [70.1;85.6] | 74.4 [68.6;82.1] | 0.758 | 0.476 | - | - |
| Ct. Po [%] | 2.2 [1.3;3.2] | 2.2 [1.3;3.2] | 2.2 [1.3;3.3] | 1.9 [1.2;2.8] | 0.203 | 0.444 | - | - |
| Ct. pore volume [mm3] | 10.2 [6.3;17.8] | 10.1 [6.2;17.2] | 10.8 [6.4;19.4] | 11.7 [6.2;16.2] | 0.917 | 0.722 | - | - |
| Ct. pore Dm [µm] | 156 [147;172] | 154 [146;169] | 161 [148;176] | 154 [145;161] | 0.225 | 0.245 | - | - |
Bone geometry, microstructure and volumetric bone mineral density [BMD] by high resolution peripheral quantitative CT [HR-pQCT] at the ultradistal radius. Kruskal-Wallis Test for Crohn’s disease vs ulcerative colitis vs controls; only parameters with significant differences in Kruskal-Wallis-Test calculated with Mann Whitney U-test [comparison CD vs CO and UC vs CO]. Results are median [25th;75th percentile]. Bold indicates significant differences (p < 0.05).
IBD, inflammatory bowel disease; CD, Crohn’s disease; UC, ulcerative colitis; CO, controls; Ct., cortical; Tb., trabecular; Tb. meta BMD, peripheral trabecular density adjacent to cortex; Tb. inn BMD, central medullary trabecular density; BV/TV, trabecular bone volume; N, number, Th, thickness; Sp, separation; Pm, perimeter; Po, porosity; Dm, diameter.