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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Infect Genet Evol. 2016 Jun 4;43:289–296. doi: 10.1016/j.meegid.2016.06.008

Figure 4. Lm-OVA-immune mice restrict Yptb-OVA burden early but eventually succumb to infection.

Figure 4

C57BL/6 mice were immunized with 3 ×107 CFU Lm or Lm-OVA, then 60 days later challenged with 100 CFU Yptb-OVA. Mice were sacrificed upon observation of morbidity and (A) day of death noted. Results shown are pooled from 3 separate experiments. Lm or Lm-OVA-immune mice were challenged with 150 clones of a Lm-OVA clone library, sacrificed at days 1, 7 and output bacterial burden (B, C) and clone numbers (D, E) in the spleen (B, D) and liver (D, E) determined. ND, not detected. Results shown are from two separate experiments.