Skip to main content
. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Pain. 2016 Jan;157(1):147–158. doi: 10.1097/j.pain.0000000000000342

Fig. 6.

Fig. 6

Both in vitro and in vivo application of the GluN2B selective antagonist Ro 25-6981 inhibited NMDA induced currents more prominently in morphine (Mor) treated rats than in controls (Sal). (A) Upper: representative currents induced by NMDA application before and after bath application of Ro 25-6981 in small diameter DRG neurons (≤ 30 μm) from saline treated rats. Lower: Currents recorded in small DRG neurons from morphine treated rats. (B) Histogram showing the inhibitory effect of Ro 25-6981 in morphine vs. saline treated rats (** p ≤ 0.01). (C) Left: representative trace shows NMDA induced current in a small DRG neuron from a morphine treated rat. Right: NMDA induced current in a small DRG neuron from a morphine + Ro 25-6981 treated rat. (D) Application of Ro 25-6981 blocked the enhancement of NMDA induced currents in small DRG neurons caused by morphine administration (**, p ≤ 0.01). Integers in each column represent sample numbers.