Table 4.

Odds ratios of having ipsi-compartmental cartilage loss due to risk factors in the same compartment (i.e. medial cartilage thinning with medial risk factors, and lateral cartilage thinning with lateral risk factors)

Risk factor at baseline	No. of compartments without cartilage loss (medial + lateral) (N=321) n (%)	No. of compartments with cartilage loss (medial+lateral): (N=64) n (%)	aOR (95% CI)	p-value **
Meniscal damage WORMS score ≥1 *	49 15.26	25 39.68	3.94*** (2.09, 7.43)	<0.0001
Meniscal extrusion (present)*	59 18.50	28 44.44	2.92*** (1.62, 5.26)	0.0004
Cartilage WORMS score ≥2*	183 57.01	48 76.19	2.27*** (1.18, 4.37)	0.0136
BML WORMS score ≥1 *	85 26.48	26 41.27	1.53*** (0.85, 2.74)	0.1523
Effusion synovitis WORMS score ≥1 *	224 69.78	46 73.02	1.71*** (0.82, 3.53)	0.1499
Hoffa synovitis WORMS score ≥1 *	187 58.26	35 55.56	0.79*** (0.43, 1.47)	0.4640
Radiographic OA (KL grade ≥2)	45 13.72	23 35.94	4.79**** (2.41, 9.53)	<0.0001

^*4 subjects had missing WORMS reading for this feature and were excluded from analysis

^**p<0.023 is considered statistically significant, after Bonferroni correction for multiple comparisons

^***Adjusted for age, BMI, gender, clinic site, alignment and KL grade

^****Adjusted for age, BMI, gender, clinic site, and alignment