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Evaluation of ABT-263 in RS4;11 xenografts or sublines treated with SAR405838. A, Representative RS4;11 sublines were treated with ABT-263 for 24 h and biochemical markers of apoptosis were analyzed by immunoblotting. B, RS4;11 parental and sublines were treated with ABT-263 for 4 days and cell viability was determined by a WST assay. C, Cells were treated with ABT-263 for 24 h for apoptosis analysis by flow cytometry with Annexin V/P.I. double staining.
