Table 1.

Differentially expressed genes in Aminaphtone-treated vs. untreated IL-1β-stimulated ECV304 endothelial cells.

Symbol	Gene name	Gene ID	FDR	Ptreatment	Pinteraction	FC AMNA/IL-1β			Pairwise
						FC 1 h	FC 3 h	FC 6 h	1 h	3 h	6 h
AAK1	AP2 associated kinase 1	22848	9.13e-02	5.98e-03	7.26e-01	1.55	1.66	1.31		*
ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	9744	1.65e-02	2.07e-04	4.01e-01	−1.50	−1.23	−1.36	**		*
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	116986	1.73e-03	8.86e-05	4.53e-01	−1.39	−1.58	−1.31	**	**	*
AK4	adenylate kinase 4	205	8.79e-03	4.27e-01	7.56e-04	1.41	−1.01	−1.64	*		**
ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	27063	8.02e-03	2.75e-02	1.23e-02	1.26	−1.46	−1.78		*	**
ANKRD13A	ankyrin repeat domain 13A	88455	8.98e-02	2.37e-04	1.88e-01	1.23	1.47	1.18	*	**
ANXA3	annexin A3	306	4.39e-04	7.76e-02	7.05e-04	1.48	−1.33	−1.70	**	*	**
AREG	amphiregulin	374	7.88e-02	6.01e-03	6.32e-01	−1.37	−1.39	−1.78			*
ARHGEF26	Rho guanine nucleotide exchange factor (GEF) 26	26084	7.10e-02	1.36e-03	9.35e-01	1.42	1.33	1.42	*		*
ARL4C	ADP-ribosylation factor-like 4C	10123	2.31e-02	2.22e-04	8.41e-01	−1.41	−1.30	−1.39	**		**
ATF7IP2	activating transcription factor 7 interacting protein 2	80063	5.87e-02	5.59e-03	1.69e-01	1.77	1.17	1.22	**
BCL2L11	BCL2-like 11 (apoptosis facilitator)	10018	8.59e-04	7.06e-05	3.23e-02	1.60	1.48	1.09	**	**	*
BCL3	B-cell CLL/lymphoma 3	602	4.12e-03	3.18e-02	5.00e-03	−1.98	−1.05	1.13	**
BMP6	bone morphogenetic protein 6	654	1.78e-02	3.25e-03	6.12e-02	−1.00	1.65	1.47		**	*
BNIP3	BCL2/adenovirus E1B 19 kDa interacting protein 3	664	0.00e+00	3.64e-05	4.09e-06	1.11	−1.12	−2.54			**
BRCA1	breast cancer 1, early onset	672	7.46e-02	4.42e-01	1.64e-02	1.96	−1.28	−1.15	**
BUB1	BUB1 mitotic checkpoint serine/threonine kinase	699	1.40e-02	5.76e-01	5.38e-03	1.93	−1.28	−1.26	**
BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	701	5.11e-02	4.12e-01	1.69e-02	2.09	−1.32	−1.14	**
C14orf105	chromosome 14 open reading frame 105	55195	6.13e-02	4.75e-03	5.28e-01	−1.22	−1.59	−1.62		*	*
C15orf48	chromosome 15 open reading frame 48	84419	5.83e-03	7.16e-05	4.51e-02	−1.61	−1.17	−1.25	**		*
C1orf63	chromosome 1 open reading frame 63	57035	3.07e-03	1.82e-04	3.43e-01	1.61	1.27	1.38	**		*
C2orf44	chromosome 2 open reading frame 44	80304	9.87e-03	1.63e-03	2.02e-01	1.79	1.35	1.20	**
C3orf58	chromosome 3 open reading frame 58	205428	1.08e-05	3.22e-01	1.35e-06	1.54	1.17	−1.61	**	*	**
C7orf53	chromosome 7 open reading frame 53	286006	6.37e-05	1.06e-03	1.05e-02	2.19	1.05	1.27	**
C9orf131	chromosome 9 open reading frame 131	138724	9.82e-03	4.39e-04	7.67e-02	1.67	1.21	1.19	**
CACHD1	cache domain containing 1	57685	4.66e-02	2.02e-03	4.84e-01	1.31	1.63	1.29		**
CBLB	Cbl proto-oncogene, E3 ubiquitin protein ligase B	868	8.71e-02	1.29e-02	2.19e-01	1.07	1.86	1.45		*
CCL22	chemokine (C–C motif) ligand 22	6367	0.00e+00	6.98e-06	6.53e-02	−1.36	−2.20	−1.99	*	**	**
CD70	CD70 molecule	970	9.39e-02	1.09e-03	2.37e-01	−1.53	−1.22	−1.20	**
CD83	CD83 molecule	9308	1.63e-03	4.10e-04	8.35e-02	1.80	1.22	1.27	**
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	1052	6.06e-03	4.58e-01	6.34e-04	−1.70	1.12	1.31	**		*
CENPF	centromere protein F, 350/400 kDa	1063	8.68e-02	6.92e-01	2.45e-02	1.90	−1.75	−1.31	*
CEP55	centrosomal protein 55 kDa	55165	4.42e-02	7.14e-01	8.10e-03	1.68	−1.40	−1.35	*
CEP76	centrosomal protein 76 kDa	79959	7.67e-02	2.29e-03	1.52e-01	1.57	1.32	1.09	**	*
CHCHD7	coiled-coil-helix-coiled-coil-helix domain containing 7	79145	6.62e-02	3.19e-03	4.05e-01	1.58	1.47	1.17	*	*
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	10370	7.93e-02	2.38e-01	3.69e-03	−1.38	1.47	1.22	*	**
CKAP2L	cytoskeleton associated protein 2-like	150468	1.53e-02	1.45e-01	1.89e-02	1.57	−1.97	−1.57		*
CLEC4E	C-type lectin domain family 4, member E	26253	4.03e-03	8.42e-04	3.66e-01	−1.25	−1.53	−1.71		*	**
CNNM4	cyclin M4	26504	1.79e-07	9.46e-05	4.77e-04	−1.11	2.00	1.57		**	**
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	1437	1.02e-03	8.79e-04	7.21e-01	−1.68	−1.88	−1.48	*	**
CTH	cystathionase (cystathionine gamma-lyase)	1491	6.66e-03	1.90e-04	3.46e-01	1.29	1.59	1.31	*	**	*
CTSK	cathepsin K	1513	2.91e-03	4.28e-04	9.47e-01	1.54	1.53	1.45	*	*	*
CUZD1	CUB and zona pellucida-like domains 1	50624	7.05e-02	3.72e-02	4.52e-02	1.95	1.02	1.05	**
CX3CL1	chemokine (C-X3-C motif) ligand 1	6376	1.25e-02	3.11e-03	4.58e-01	−1.94	−1.48	−1.33	**
CXCL3	chemokine (C-X-C motif) ligand 3	2921	8.34e-02	1.65e-02	5.71e-02	−1.70	−1.34	1.07	**
CXCL6	chemokine (C-X-C motif) ligand 6	6372	2.85e-03	1.69e-04	6.11e-01	−1.39	−1.34	−1.58	*	*	**
CYB5D1	cytochrome b5 domain containing 1	124637	2.40e-03	1.21e-03	7.39e-02	1.78	1.50	1.07	**	*
CYP24A1	cytochrome P450, family 24, subfamily A, polypeptide 1	1591	2.62e-05	4.54e-05	7.89e-01	−1.52	−1.69	−1.51	**	**	**
DBR1	debranching enzyme homolog 1 (Saccharomyces cerevisiae)	51163	7.97e-02	1.06e-03	4.21e-01	1.52	1.26	1.24	**
DDIT4	DNA-damage-inducible transcript 4	54541	5.57e-04	5.87e-04	5.05e-01	−1.90	−1.40	−1.57	**		*
DDR1	discoidin domain receptor tyrosine kinase 1	780	1.43e-02	1.48e-03	8.30e-02	−1.73	−1.26	−1.13	**
DENND2C	DENN/MADD domain containing 2C	163259	3.14e-02	1.33e-03	9.57e-01	1.44	1.49	1.40	*	*	*
DEPDC1	DEP domain containing 1	55635	5.44e-02	9.05e-01	1.02e-02	1.75	−1.26	−1.44	*
DKK1	dickkopf 1 homolog (Xenopus laevis)	22943	2.94e-05	5.83e-05	1.71e-02	−1.25	−1.25	−1.94			**
DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	10301	7.23e-02	5.02e-03	1.27e-01	1.71	1.19	1.14	**
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	9787	4.29e-03	1.58e-01	2.80e-03	1.51	−1.58	−1.42	*	*	*
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	3337	1.36e-02	4.99e-03	4.35e-02	1.82	1.31	1.00	**
DUSP8	dual specificity phosphatase 8	1850	5.16e-03	1.05e-02	4.26e-03	−1.87	1.06	−1.07	**
EBI3	Epstein-Barr virus induced 3	10148	0.00e+00	6.30e-06	6.87e-01	−1.82	−1.73	−2.06	**	**	**
ECT2	epithelial cell transforming sequence 2 oncogene	1894	6.84e-03	5.43e-02	1.07e-02	1.36	−1.84	−1.45		**
EDN1	endothelin 1	1906	0.00e+00	2.33e-06	8.60e-01	−1.79	−1.93	−1.97	**	**	**
EFNA1	ephrin-A1	1942	4.91e-03	1.20e-03	2.03e-02	−1.74	−1.02	−1.31	**		*
EFNB2	ephrin-B2	1948	1.76e-02	3.27e-03	1.81e-01	1.81	1.40	1.13	**
EGR2	early growth response 2	1959	7.52e-03	3.57e-03	6.43e-03	−1.80	−1.04	−1.06	**
EIF4B	eukaryotic translation initiation factor 4B	1975	3.63e-02	4.03e-01	9.48e-03	1.56	−1.22	−1.69	*		*
EIF4EBP2	eukaryotic translation initiation factor 4E binding protein 2	1979	3.09e-04	5.53e-06	1.55e-01	1.25	1.56	1.42	*	**	**
ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	1999	6.05e-02	3.62e-02	8.45e-03	−1.24	1.43	1.43		*	*
ELMSAN1	ELM2 and Myb/SANT-like domain containing 1	91748	3.96e-05	1.34e-02	1.00e-05	−1.86	1.19	1.08	**	*
ELOVL4	ELOVL fatty acid elongase 4	6785	8.64e-03	5.29e-04	3.98e-01	1.40	1.62	1.25	*	**
ELOVL6	ELOVL fatty acid elongase 6	79071	7.35e-02	1.86e-01	1.29e-02	1.84	−1.08	−1.15	**
ENO2	enolase 2 (gamma, neuronal)	2026	6.53e-05	1.50e-03	1.22e-02	−1.27	−1.06	−2.31			**
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	54821	6.72e-02	8.17e-01	1.39e-02	1.75	−1.58	−1.21	*
ERF	Ets2 repressor factor	2077	1.91e-02	4.84e-04	1.05e-01	−1.62	−1.22	−1.19	**
EVA1A	eva-1 homolog A (Caenorhabditis elegans)	84141	1.25e-06	3.14e-07	4.49e-03	−1.19	−1.47	−1.74	*	**	**
FAM102A	family with sequence similarity 102, member A	399665	3.29e-02	6.69e-02	5.48e-03	−1.32	1.41	1.48		*	*
FAM111B	family with sequence similarity 111, member B	374393	7.05e-02	5.89e-01	2.31e-02	2.18	−1.58	−1.06	*
FAM46C	family with sequence similarity 46, member C	54855	5.99e-04	5.82e-04	4.90e-03	1.87	1.20	1.03	**
FAM72D	family with sequence similarity 72, member D	728833	2.54e-04	4.65e-01	1.25e-03	1.86	−1.60	−1.46	**	*	*
FBLIM1	filamin binding LIM protein 1	54751	1.21e-03	1.31e-04	5.98e-01	−1.61	−1.38	−1.39	**	*	*
FBXL20	F-box and leucine-rich repeat protein 20	84961	1.87e-04	2.46e-04	6.47e-02	1.19	1.91	1.40		**	*
FBXO33	F-box protein 33	254170	4.21e-02	9.72e-04	7.70e-02	1.22	1.62	1.13		**
FLJ36840	uncharacterized LOC645524	645524	2.12e-02	1.52e-01	2.64e-02	2.66	−1.34	1.09	**
FOS	FBJ murine osteosarcoma viral oncogene homolog	2353	4.65e-06	4.26e-04	3.84e-04	2.13	1.01	1.08	**
FRMD6	FERM domain containing 6	122786	4.02e-02	1.16e-02	3.29e-02	1.11	−1.49	−1.57		*	**
FRMD8	FERM domain containing 8	83786	3.02e-02	6.15e-03	2.25e-02	−1.72	−1.23	1.03	**
FST	follistatin	10468	7.49e-02	1.12e-03	1.27e-01	−1.07	−1.44	−1.42		**	**
FUT11	fucosyltransferase 11 (alpha (1,3) fucosyltransferase)	170384	5.23e-02	1.79e-03	6.02e-03	−1.14	1.00	−1.62			**
GAN	gigaxonin	8139	4.82e-02	6.57e-03	1.16e-01	1.80	1.22	1.12	**
GAREM	GRB2 associated, regulator of MAPK1	64762	9.44e-02	1.61e-03	1.88e-02	−1.00	1.54	1.23		**	*
GAS2L3	growth arrest-specific 2 like 3	283431	5.77e-02	2.78e-01	1.30e-02	1.92	−1.14	−1.17	**
GCLC	glutamate-cysteine ligase, catalytic subunit	2729	3.29e-02	2.08e-03	7.58e-01	1.56	1.53	1.32	*	*
GCLM	glutamate–cysteine ligase, modifier subunit	2730	1.37e-02	1.51e-03	5.69e-01	1.71	1.40	1.35	**
GLCCI1	glucocorticoid induced transcript 1	113263	2.69e-02	1.03e-04	8.16e-01	1.37	1.38	1.28	**	**
GPR56	G protein-coupled receptor 56	9289	1.49e-02	3.94e-03	7.47e-02	−1.85	−1.09	−1.27	**
GPR89A	G protein-coupled receptor 89A	653519	5.78e-02	3.12e-03	3.52e-01	1.67	1.32	1.22	**
GRB7	growth factor receptor-bound protein 7	2886	1.09e-02	1.07e-03	5.88e-02	−1.74	−1.18	−1.18	**
GTF2B	general transcription factor IIB	2959	6.15e-04	8.75e-05	1.99e-01	1.69	1.35	1.29	**	*	*
HCAR1	hydroxycarboxylic acid receptor 1	27198	9.99e-02	3.02e-03	7.95e-01	−1.29	−1.45	−1.49		*	*
HILPDA	hypoxia inducible lipid droplet-associated	29923	7.25e-05	9.73e-04	3.21e-03	−1.20	−1.01	−2.09			**
HIST1H2AK	histone cluster 1, H2ak	8330	3.09e-03	2.95e-03	1.11e-01	−1.05	−1.71	−1.85		*	**
HIST2H2BF	histone cluster 2, H2bf	440689	4.80e-03	4.43e-05	6.62e-01	1.36	1.32	1.47	**	*	**
HIST2H4A	histone cluster 2, H4a	8370	0.00e+00	4.91e-07	1.85e-02	1.87	1.46	1.32	**	**	**
HK2	hexokinase 2	3099	1.25e-06	4.59e-04	1.65e-03	1.06	−1.37	−2.25		*	**
HMMR	hyaluronan-mediated motility receptor (RHAMM)	3161	1.23e-02	2.21e-01	8.49e-03	1.58	−1.43	−1.71	*		*
HMOX1	heme oxygenase (decycling) 1	3162	1.69e-02	3.20e-04	3.02e-01	−1.51	−1.19	−1.41	**		**
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	3398	5.45e-03	1.51e-04	1.15e-02	1.38	1.58	1.03	**	**
IDI1	isopentenyl-diphosphate delta isomerase 1	3422	6.89e-02	4.10e-03	2.47e-01	1.70	1.21	1.23	**
IGFL1	IGF-like family member 1	374918	0.00e+00	1.06e-05	8.05e-01	−2.11	−2.05	−2.41	**	**	**
IL1B	interleukin 1, beta	3553	2.12e-03	1.50e-03	3.88e-01	−1.29	−1.92	−1.69		**	*
IL32	interleukin 32	9235	3.56e-03	8.70e-05	1.94e-01	−1.23	−1.34	−1.59		**	**
IL7R	interleukin 7 receptor	3575	2.09e-04	7.60e-04	8.60e-02	−1.11	−1.95	−1.69		**	**
IRF2BP2	interferon regulatory factor 2 binding protein 2	359948	1.26e-02	7.17e-02	2.00e-04	−1.65	1.11	1.13	**
ISCA1	iron–sulfur cluster assembly 1 homolog (S. cerevisiae)	81689	2.42e-02	2.41e-03	1.97e-01	1.60	1.54	1.10	**	*
ISG20L2	interferon stimulated exonuclease gene 20 kDa-like 2	81875	8.45e-02	4.01e-02	2.40e-03	−1.62	1.08	1.03	**
KCTD11	potassium channel tetramerisation domain containing 11	147040	4.26e-05	1.92e-04	3.55e-01	−1.91	−1.36	−1.65	**		**
KDELC1	KDEL (Lys-Asp-Glu-Leu) containing 1	79070	5.23e-02	7.58e-05	3.32e-01	1.20	1.43	1.30		**	**
KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3	10656	1.79e-03	2.61e-06	7.74e-04	1.05	1.57	1.32		**	**
KIAA0922	KIAA0922	23240	1.60e-02	1.12e-03	3.47e-01	1.25	1.68	1.35		**
KIAA1524	KIAA1524	57650	2.09e-02	3.06e-01	1.10e-02	1.64	−1.68	−1.44	*	*
KIF14	kinesin family member 14	9928	1.42e-02	8.55e-01	1.29e-02	2.46	−1.70	−1.31	*
KIF23	kinesin family member 23	9493	7.31e-02	1.00e+00	1.64e-02	1.88	−1.46	−1.29	*
KLRAP1	killer cell lectin-like receptor subfamily A pseudogene 1	10748	9.99e-02	9.35e-01	2.08e-02	1.86	−1.58	−1.22	*
KRT16	keratin 16	3868	8.89e-04	7.06e-04	5.60e-01	−1.73	−1.76	−1.37	*	**
KRT17	keratin 17	3872	1.35e-03	6.95e-04	2.03e-01	−1.86	−1.24	−1.43	**		*
KRT34	keratin 34	3885	6.82e-02	5.18e-04	8.08e-01	−1.27	−1.37	−1.40			**
LAMB3	laminin, beta 3	3914	9.31e-03	7.05e-04	8.37e-01	−1.57	−1.44	−1.39	**	*	*
LIF	leukemia inhibitory factor	3976	1.04e-03	1.87e-02	1.93e-03	−1.34	1.51	1.62	*	**	**
LMCD1	LIM and cysteine-rich domains 1	29995	7.13e-02	2.87e-04	8.53e-01	−1.38	−1.33	−1.28	**
LOC100130713	uncharacterized LOC100130713	100130713	8.73e-03	3.78e-02	1.06e-03	−1.33	1.51	1.34	*	**	*
LOC440896	uncharacterized LOC440896	440896	1.04e-02	7.89e-04	8.40e-01	−1.55	−1.49	−1.37	*	*
LOX	lysyl oxidase	4015	2.52e-02	2.34e-04	3.94e-02	−1.15	−1.19	−1.60			**
LPIN1	lipin 1	23175	1.40e-03	2.40e-04	4.71e-02	1.72	1.37	1.12	**	*
MARCH8	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	220972	7.20e-02	2.41e-03	2.60e-01	1.12	1.54	1.42		**	*
MEF2D	myocyte enhancer factor 2D	4209	4.21e-03	9.11e-02	1.55e-03	−1.84	1.24	−1.00	**
MEGF9	multiple EGF-like-domains 9	1955	1.01e-04	2.69e-04	9.48e-01	1.62	1.76	1.69	*	**	*
MERTK	c-mer proto-oncogene tyrosine kinase	10461	6.83e-05	2.96e-05	6.07e-02	1.28	1.79	1.32	*	**	*
MINPP1	multiple inositol-polyphosphate phosphatase 1	9562	4.12e-02	2.07e-03	6.87e-01	1.51	1.54	1.28	*	*
MIR29A	microRNA 29a	407021	6.91e-05	9.06e-04	3.57e-01	1.59	1.74	2.69			**
MKI67	antigen identified by monoclonal antibody Ki-67	4288	2.28e-02	6.57e-01	1.27e-02	2.18	−1.58	−1.13	**
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	4312	1.40e-04	1.11e-03	3.61e-02	−1.08	−1.44	−2.18		*	**
MMP10	matrix metallopeptidase 10 (stromelysin 2)	4319	5.96e-08	1.29e-04	1.54e-03	−1.02	−1.38	−2.37		*	**
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	4314	1.93e-05	1.63e-03	2.51e-02	−1.01	−1.63	−2.57	*	*	**
MOB3C	MOB kinase activator 3C	148932	2.40e-02	1.54e-02	7.70e-03	−1.78	1.01	−1.02	**
MYLIP	myosin regulatory light chain interacting protein	29116	0.00e+00	9.67e-07	8.89e-05	2.84	1.52	1.12	**	**
NAV3	neuron navigator 3	89795	7.05e-02	6.46e-01	6.03e-03	1.55	−1.42	−1.24	*	*
NCAPG	non-SMC condensin I complex, subunit G	64151	8.61e-02	7.39e-01	1.66e-02	1.89	−1.41	−1.18	*
NEK2	NIMA-related kinase 2	4751	5.47e-02	2.39e-01	7.63e-03	1.78	−1.23	−1.04	**
NINJ1	ninjurin 1	4814	6.07e-02	5.10e-03	8.39e-02	−1.70	−1.25	−1.06	**
NIPAL4	NIPA-like domain containing 4	348938	4.83e-03	6.92e-04	3.07e-01	−1.74	−1.31	−1.32	**
NR4A2	nuclear receptor subfamily 4, group A, member 2	4929	2.09e-03	5.30e-01	1.08e-03	−1.85	1.21	1.31	**
NUAK2	NUAK family, SNF1-like kinase, 2	81788	1.41e-02	3.76e-04	1.70e-01	−1.60	−1.19	−1.30	**		*
NXF1	nuclear RNA export factor 1	10482	1.95e-02	4.17e-04	7.68e-02	1.19	1.63	1.20		**
OLFM2	olfactomedin 2	93145	9.51e-02	4.42e-03	7.98e-02	−1.65	−1.13	−1.14	**
OSBPL11	oxysterol binding protein-like 11	114885	9.51e-02	8.43e-03	4.90e-01	1.84	1.30	1.37	*
OXTR	oxytocin receptor	5021	1.11e-03	9.51e-06	5.52e-03	−1.10	−1.62	−1.32		**	**
P4HA1	prolyl 4-hydroxylase, alpha polypeptide I	5033	1.04e-04	4.09e-01	3.61e-04	1.58	−1.02	−1.89	**		**
PCF11	PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)	51585	2.42e-02	3.67e-02	3.25e-02	2.13	−1.01	1.06	**
PDGFB	platelet-derived growth factor beta polypeptide	5155	2.00e-04	6.09e-04	9.34e-02	−2.09	−1.26	−1.36	**
PDK1	pyruvate dehydrogenase kinase, isozyme 1	5163	1.91e-06	2.69e-02	4.56e-04	1.44	−1.19	−2.37	*		**
PDZK1IP1	PDZK1 interacting protein 1	10158	3.32e-02	2.18e-03	6.99e-02	−1.60	−1.03	−1.39	**		*
PER1	period circadian clock 1	5187	1.43e-02	6.69e-02	3.66e-03	−1.84	1.08	1.08	**
PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	5210	0.00e+00	3.32e-04	6.63e-05	−1.06	1.04	−2.67			**
PHLDA3	pleckstrin homology-like domain, family A, member 3	23612	4.60e-02	7.89e-04	5.33e-01	−1.52	−1.27	−1.31	**		*
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	5295	2.59e-03	1.84e-02	2.19e-02	2.40	1.14	−1.02	**
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	8503	1.86e-02	4.86e-04	5.59e-01	1.28	1.54	1.37		**	*
PLAT	plasminogen activator, tissue	5327	3.74e-02	1.90e-02	1.06e-01	−2.20	−1.18	−1.12	**
PLCB4	phospholipase C, beta 4	5332	7.45e-06	3.68e-02	2.37e-03	1.73	−2.07	−2.14	*	**	**
PLEKHG2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	64857	3.71e-02	3.43e-03	7.01e-02	−1.72	−1.23	−1.08	**
PLEKHM1	pleckstrin homology domain containing, family M (with RUN domain) member 1	9842	8.05e-02	9.03e-02	1.43e-02	−1.28	1.65	1.26		**
PLEKHM3	pleckstrin homology domain containing, family M, member 3	389072	3.51e-02	4.36e-03	9.12e-01	1.57	1.78	1.56		*
PODXL	podocalyxin-like	5420	1.55e-02	8.88e-04	9.91e-03	−1.05	−1.16	−1.69			**
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	5422	9.69e-02	3.40e-01	2.19e-02	1.95	−1.35	−1.00	**
PPP1R18	protein phosphatase 1, regulatory subunit 18	170954	2.09e-02	7.61e-03	1.02e-02	−1.77	−1.06	−1.02	**
PPP1R3C	protein phosphatase 1, regulatory subunit 3C	5507	1.19e-02	9.34e-03	7.03e-02	1.04	−1.54	−1.94		*	**
PRDM1	PR domain containing 1, with ZNF domain	639	0.00e+00	1.29e-05	3.46e-06	−2.47	−1.04	−1.01	**
PRKCA	protein kinase C, alpha	5578	3.16e-03	6.04e-04	9.57e-01	1.48	1.59	1.54	*	*	*
PRSS22	protease, serine, 22	64063	2.23e-02	3.34e-04	8.39e-01	−1.41	−1.43	−1.31	**	**
PTCH1	patched 1	5727	8.87e-02	1.19e-02	6.15e-03	−1.02	1.65	1.04		**
PTP4A3	protein tyrosine phosphatase type IVA, member 3	11156	1.22e-04	2.90e-04	3.74e-01	−1.51	−1.95	−1.41	*	**
PXDC1	PX domain containing 1	221749	3.90e-02	3.71e-01	2.02e-03	−1.66	1.16	1.19	**
RAI14	retinoic acid induced 14	26064	9.76e-02	7.26e-01	1.68e-02	1.87	−1.31	−1.26	*
RASD2	RASD family, member 2	23551	6.21e-02	7.34e-04	2.19e-02	−1.58	−1.08	−1.15	**
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	83593	9.60e-02	2.47e-04	6.95e-01	−1.29	−1.39	−1.25		**
RIPK4	receptor-interacting serine–threonine kinase 4	54101	1.33e-03	3.07e-04	1.37e-02	−1.79	−1.10	−1.23	**
RND1	Rho family GTPase 1	27289	9.23e-03	1.56e-02	5.23e-02	−1.12	1.59	2.06			**
RNF103	ring finger protein 103	7844	6.68e-02	2.52e-03	9.20e-01	1.44	1.51	1.37	*	*
RRM2	ribonucleotide reductase M2	6241	5.93e-02	3.12e-03	1.19e-02	1.59	1.22	−1.04	**
S100A3	S100 calcium binding protein A3	6274	0.00e+00	7.47e-06	5.36e-02	−2.37	−1.37	−2.05	**		**
SAMD4A	sterile alpha motif domain containing 4A	23034	7.19e-04	4.28e-06	7.70e-02	1.22	1.56	1.36	*	**	**
SELE	selectin E	6401	2.45e-03	2.50e-03	1.08e-02	−1.01	1.24	1.89			**
SEMA4C	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	54910	9.90e-02	1.27e-03	8.89e-02	−1.53	−1.26	−1.08	**	*
SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	12	2.93e-03	4.08e-03	1.68e-01	−2.38	−1.29	−1.37	**
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	5272	4.70e-02	4.96e-03	1.48e-01	−1.07	−1.39	−1.72			**
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	871	6.23e-02	1.47e-03	4.28e-01	−1.27	−1.27	−1.58			**
SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	5274	2.82e-02	1.25e-03	6.61e-01	1.54	1.28	1.46	*		*
SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	6513	2.93e-03	1.28e-03	6.12e-02	−1.23	−1.19	−1.91			**
SLC33A1	solute carrier family 33 (acetyl-CoA transporter), member 1	9197	6.24e-02	6.09e-04	3.29e-01	1.42	1.42	1.16	**	**
SLC35D1	solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1	23169	5.29e-02	3.06e-03	6.97e-01	1.65	1.38	1.35	*
SLC6A14	solute carrier family 6 (amino acid transporter), member 14	11254	8.97e-02	5.67e-03	8.88e-02	1.01	−1.46	−1.50		*	*
SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	6535	2.16e-03	1.14e-03	1.69e-02	−1.03	1.70	1.47		**	**
SMIM14	small integral membrane protein 14	201895	7.25e-02	3.85e-03	4.08e-01	1.19	1.64	1.41		*
SNHG12	small nucleolar RNA host gene 12 (non-protein coding)	85028	2.55e-04	1.61e-05	6.39e-02	1.66	1.38	1.21	**	**	*
SNORA61	small nucleolar RNA, H/ACA box 61	677838	7.99e-04	6.54e-05	7.40e-02	1.62	1.45	1.15	**	**
SNORD105	small nucleolar RNA, C/D box 105	692229	1.18e-02	5.73e-03	9.15e-02	−1.82	−1.58	−1.00	**	*
SNORD13P2	small nucleolar RNA, C/D box 13 pseudogene 2	6077	1.60e-02	8.33e-02	5.74e-03	−1.88	1.16	1.01	**
SNORD14E	small nucleolar RNA, C/D box 14E	85391	1.44e-02	1.01e-02	9.15e-02	2.17	1.21	1.14	**
SNORD22	small nucleolar RNA, C/D box 22	9304	1.49e-06	3.21e-04	3.16e-02	2.57	1.32	1.34	**
SNORD28	small nucleolar RNA, C/D box 28	9300	4.12e-02	1.90e-03	1.47e-01	1.66	1.14	1.26	**
SNORD30	small nucleolar RNA, C/D box 30	9299	1.45e-02	3.29e-03	4.36e-02	1.82	1.11	1.16	**
SNORD31	small nucleolar RNA, C/D box 31	9298	5.13e-06	9.26e-05	3.20e-03	2.08	1.18	1.17	**
SNORD32A	small nucleolar RNA, C/D box 32A	26819	6.96e-02	1.74e-02	3.10e-02	−1.66	−1.32	1.11	**
SPRY4	sprouty homolog 4 (Drosophila)	81848	8.04e-02	2.15e-03	1.03e-01	−1.59	−1.09	−1.25	**
SRGN	serglycin	5552	1.96e-02	1.14e-04	7.38e-02	−1.15	−1.28	−1.55		*	**
STAT5A	signal transducer and activator of transcription 5A	6776	8.68e-02	6.33e-04	6.45e-01	−1.22	−1.38	−1.40			**
STC1	stanniocalcin 1	6781	8.00e-04	1.62e-03	1.37e-02	−1.21	−1.06	−2.01			**
STC2	stanniocalcin 2	8614	9.30e-04	1.85e-03	5.42e-03	1.01	−1.19	−1.93			**
STK17B	serine/threonine kinase 17b	9262	1.23e-03	1.93e-03	1.18e-01	2.15	1.36	1.23	**
STX4	syntaxin 4	6810	2.28e-03	1.23e-04	9.23e-01	−1.49	−1.40	−1.43	**	*	**
SYDE1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	85360	9.00e-02	9.80e-04	4.81e-01	−1.43	−1.19	−1.40	**		*
TAGLN	transgelin	6876	3.45e-03	3.65e-04	6.89e-01	−1.43	−1.37	−1.61	*	*	**
TAS2R4	taste receptor, type 2, member 4	50832	9.62e-02	1.10e-02	1.86e-01	1.83	1.15	1.22	**
TFRC	transferrin receptor (p90, CD71)	7037	7.32e-02	3.99e-01	2.32e-02	2.18	−1.21	−1.23	**
TGFB1I1	transforming growth factor beta 1 induced transcript 1	7041	8.92e-05	2.58e-05	9.24e-01	−1.47	−1.48	−1.55	**	**	**
TGFB2	transforming growth factor, beta 2	7042	1.50e-05	2.51e-03	3.22e-03	1.19	−2.14	−1.52		**	*
TICAM1	toll-like receptor adaptor molecule 1	148022	4.13e-03	8.38e-03	8.32e-04	−1.79	1.05	1.01	**
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	7088	3.37e-03	1.25e-02	3.72e-04	−1.23	1.70	1.14	*	**
TM4SF18	transmembrane 4L six family member 18	116441	3.05e-02	6.72e-02	2.10e-03	1.31	−1.24	−1.55	*		**
TMEM2	transmembrane protein 2	23670	2.67e-02	5.08e-03	6.27e-01	2.00	1.44	1.53	*
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	7130	1.27e-02	4.06e-03	2.87e-01	−1.16	−1.70	−1.84		*	*
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	4982	6.74e-06	4.09e-04	2.27e-01	−1.49	−2.62	−1.70		**	*
TNFSF18	tumor necrosis factor (ligand) superfamily, member 18	8995	0.00e+00	3.06e-06	3.10e-01	−2.41	−4.24	−3.41	**	**	**
TOP2A	topoisomerase (DNA) II alpha 170 kDa	7153	4.62e-02	8.29e-01	1.18e-02	1.90	−1.42	−1.24	**
TRAF1	TNF receptor-associated factor 1	7185	2.49e-04	8.97e-05	2.32e-01	−1.69	−1.50	−1.26	**	**
TRIP6	thyroid hormone receptor interactor 6	7205	8.37e-02	9.63e-04	6.24e-01	−1.48	−1.30	−1.26	**	*
TSGA10	testis specific, 10	80705	6.19e-02	6.67e-03	1.65e-02	1.68	1.07	1.04	**
TTLL3	tubulin tyrosine ligase-like family, member 3	26140	3.38e-03	1.07e-03	1.29e-02	−1.04	1.65	1.45		**	**
UBALD1	UBA-like domain containing 1	124402	1.29e-02	9.81e-02	5.00e-03	−1.88	1.23	−1.03	**
ULBP3	UL16 binding protein 3	79465	5.51e-02	3.20e-04	1.21e-01	1.30	1.50	1.12	*	**
ULK1	unc-51-like kinase 1 (C. elegans)	8408	8.48e-02	4.11e-01	2.45e-03	−1.44	1.33	1.27	**	*
USP38	ubiquitin specific peptidase 38	84640	8.54e-03	1.46e-04	4.15e-01	1.53	1.34	1.27	**	*	*
VAMP1	vesicle-associated membrane protein 1 (synaptobrevin 1)	6843	1.08e-03	3.77e-05	4.65e-01	1.49	1.48	1.28	**	**	*
VLDLR	very low density lipoprotein receptor	7436	4.04e-02	4.49e-04	2.18e-03	−1.05	−1.08	−1.61			**
ZC3H7B	zinc finger CCCH-type containing 7B	23264	6.99e-02	4.01e-04	8.97e-01	−1.39	−1.30	−1.32	**
ZC3HAV1	zinc finger CCCH-type, antiviral 1	56829	4.54e-02	3.89e-03	2.25e-01	1.74	1.29	1.17	**
ZCCHC14	zinc finger, CCHC domain containing 14	23174	3.05e-02	1.36e-03	9.05e-02	1.11	1.66	1.27		**
ZNF253	zinc finger protein 253	56242	5.52e-02	2.43e-02	1.07e-01	2.18	1.16	1.11	**
ZNF426	zinc finger protein 426	79088	6.98e-02	3.42e-03	7.62e-01	1.55	1.51	1.30	*	*
ZNF48	zinc finger protein 48	197407	5.05e-02	5.04e-03	1.14e-02	−1.67	−1.07	−1.03	**
ZNF487P	zinc finger protein 487, pseudogene	642819	5.33e-05	1.01e-03	5.62e-02	1.47	2.43	1.18		**
ZNF724P	zinc finger protein 724, pseudogene	440519	3.69e-02	1.45e-01	1.73e-02	2.07	−1.05	−1.15	**
ZNF737	zinc finger protein 737	100129842	2.08e-02	6.03e-03	3.48e-01	2.11	1.29	1.46	**
ZSWIM6	zinc finger, SWIM-type containing 6	57688	4.63e-02	5.34e-03	4.44e-01	1.55	1.78	1.22		*

P-values in bold if significant at two-factor ANOVA (<0.05).

FDR: false discovery rate, according to BETR analysis. P_treatment: P-value for treatment effect; and P_interaction: P-value for interaction effect, at two-factor ANOVA. FC: fold-change in Aminaphtone-treated vs. untreated IL-1β-stimulated endothelial cells. AMNA: Aminaphtone. Pairwise: pairwise significant at two-tailed t-test.

^*P<0.05.

^**P<0.01 at two-tailed t-test.