Table 1.

Patient Characteristics of the Discovery and Confirmatory Cohorts

	Discovery cohort (n = 347)	Confirmatory cohort (n = 236)
Median age at diagnosis (years)	62 (37.0–91)	65.1 (24–99)
Follow up time (years + IQR)	2.98 (2.41–4.17)	7 (4–10.2)
Male sex	237 (68%)	150 (64%)
Binet stage A	180 (52%)	182 (77%)
Binet stage B	155 (45%)	25 (11%)
Binet stage C	11 (3%)	27 (11%)
Missing	1	2
CD38 positive	82 (24%)	99 (42%)
CD38 negative	218 (63%)	117 (50%)
CD38 missing	47	20
Zap70 positive	93 (27%)	82 (35%)
Zap 70 negative	203 (59%)	134 (57%)
Zap 70 missing	51	20
IGHV mutated	176 (51%)	125 (53%)
IGHV unmutated	104 (30%)	40 (12%)
IGHV missing	67	71
CD49d positive	64 (18%)	102 (43.2%)
Cd49d negative	131 (38%)	69 (29.2%)
Cd49d missing	152	65
FISH
Normal	76(22%)	61(26%)
13q−	120(35%)	37(16%)
12+	50(14%)	6(3%)
11q−	22(6%)	15(6%)
17p−	11(3%)	5(2%)
Other	5(1%)	2(0.8%)
Missing	63	110